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Significance of Primary Melanoma Regression on Local Infiltrate and Outcome

INTRODUCTION: The characteristics and the prognostic value of regression in primary melanomas are controversial. OBJECTIVES: To further characterize “hot” and “cold” tumor’s stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression. METHO...

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Autores principales: Kelati, Awatef, Balme, Brigitte, Chouvet, Brigitte, Traverse-Glehen, Alexandra, Tantot, Juliette, Harou, Olivier, Duru, Gérard, Debarbieux, Sebastien, Dalle, Stephane, Thomas, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824592/
https://www.ncbi.nlm.nih.gov/pubmed/35223178
http://dx.doi.org/10.5826/dpc.1201a34
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author Kelati, Awatef
Balme, Brigitte
Chouvet, Brigitte
Traverse-Glehen, Alexandra
Tantot, Juliette
Harou, Olivier
Duru, Gérard
Debarbieux, Sebastien
Dalle, Stephane
Thomas, Luc
author_facet Kelati, Awatef
Balme, Brigitte
Chouvet, Brigitte
Traverse-Glehen, Alexandra
Tantot, Juliette
Harou, Olivier
Duru, Gérard
Debarbieux, Sebastien
Dalle, Stephane
Thomas, Luc
author_sort Kelati, Awatef
collection PubMed
description INTRODUCTION: The characteristics and the prognostic value of regression in primary melanomas are controversial. OBJECTIVES: To further characterize “hot” and “cold” tumor’s stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression. METHODS: A 14-year-collection-based retrospective analysis was carried out on 40 patients with confirmed regressive melanomas. RESULTS: The extent of regression in dermoscopy was associated with the stage of the regression (P = 0.05) and with the MelanA patterns in histology (P = 0.02). Blue-gray and gray-brown color of the peppering (P = 0.01), and the eccentric, multifocal character of the dermoscopic regression (P = 0.05) were associated with “hot” stromas (CD8+, Granzym B+). Focal histologic regression (regressing melanomas) was associated with a good outcome (P < 0.001), while a complete regression (regressed melanomas) was associated with melanoma-related death (P < 0.001). “Hot” stromas (CD8(+) were significantly associated with survival at 10 years (P = 0.044), while “hot” stromas (Granzyme B(+)) were associated with the locoregional extension (P = 0.016), and the initial distant metastasis (P = 0.016). CONCLUSIONS: Dermoscopic features of regression in primary melanomas were associated with the stage of regression, its extent, and the “hot” or “cold” nature of the tumor stroma, with prognostic implications.
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spelling pubmed-88245922022-02-25 Significance of Primary Melanoma Regression on Local Infiltrate and Outcome Kelati, Awatef Balme, Brigitte Chouvet, Brigitte Traverse-Glehen, Alexandra Tantot, Juliette Harou, Olivier Duru, Gérard Debarbieux, Sebastien Dalle, Stephane Thomas, Luc Dermatol Pract Concept Original Article INTRODUCTION: The characteristics and the prognostic value of regression in primary melanomas are controversial. OBJECTIVES: To further characterize “hot” and “cold” tumor’s stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression. METHODS: A 14-year-collection-based retrospective analysis was carried out on 40 patients with confirmed regressive melanomas. RESULTS: The extent of regression in dermoscopy was associated with the stage of the regression (P = 0.05) and with the MelanA patterns in histology (P = 0.02). Blue-gray and gray-brown color of the peppering (P = 0.01), and the eccentric, multifocal character of the dermoscopic regression (P = 0.05) were associated with “hot” stromas (CD8+, Granzym B+). Focal histologic regression (regressing melanomas) was associated with a good outcome (P < 0.001), while a complete regression (regressed melanomas) was associated with melanoma-related death (P < 0.001). “Hot” stromas (CD8(+) were significantly associated with survival at 10 years (P = 0.044), while “hot” stromas (Granzyme B(+)) were associated with the locoregional extension (P = 0.016), and the initial distant metastasis (P = 0.016). CONCLUSIONS: Dermoscopic features of regression in primary melanomas were associated with the stage of regression, its extent, and the “hot” or “cold” nature of the tumor stroma, with prognostic implications. Mattioli 1885 2022-01-01 /pmc/articles/PMC8824592/ /pubmed/35223178 http://dx.doi.org/10.5826/dpc.1201a34 Text en ©2022 Kelati et al https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Original Article
Kelati, Awatef
Balme, Brigitte
Chouvet, Brigitte
Traverse-Glehen, Alexandra
Tantot, Juliette
Harou, Olivier
Duru, Gérard
Debarbieux, Sebastien
Dalle, Stephane
Thomas, Luc
Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title_full Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title_fullStr Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title_full_unstemmed Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title_short Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
title_sort significance of primary melanoma regression on local infiltrate and outcome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824592/
https://www.ncbi.nlm.nih.gov/pubmed/35223178
http://dx.doi.org/10.5826/dpc.1201a34
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