Cargando…

Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study

BACKGROUND: higher educational attainment and less midlife cardiovascular risk factors are related to better old-age cognition. Whether education moderates the association between cardiovascular risk factors and late-life cognition is not known. We studied if higher education provides resilience aga...

Descripción completa

Detalles Bibliográficos
Autores principales: Iso-Markku, Paula, Kaprio, Jaakko, Lindgrén, Noora, Rinne, Juha O, Vuoksimaa, Eero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824709/
https://www.ncbi.nlm.nih.gov/pubmed/35134847
http://dx.doi.org/10.1093/ageing/afab228
_version_ 1784647059123470336
author Iso-Markku, Paula
Kaprio, Jaakko
Lindgrén, Noora
Rinne, Juha O
Vuoksimaa, Eero
author_facet Iso-Markku, Paula
Kaprio, Jaakko
Lindgrén, Noora
Rinne, Juha O
Vuoksimaa, Eero
author_sort Iso-Markku, Paula
collection PubMed
description BACKGROUND: higher educational attainment and less midlife cardiovascular risk factors are related to better old-age cognition. Whether education moderates the association between cardiovascular risk factors and late-life cognition is not known. We studied if higher education provides resilience against the deteriorative effects of higher middle-age body mass index (BMI) and a combination of midlife cardiovascular risk factors on old-age cognition. METHODS: the study population is the older Finnish Twin Cohort (n = 4,051, mean age [standard deviation, SD] = 45.5 years [6.5]). Cardiovascular risk factors and education were studied at baseline with questionnaires in 1975, 1981 and/or 1990 (participation rates of 89, 84 and 77%, respectively). Cognition was evaluated with telephone interviews (participation rate 67%, mean age [SD] =73.4 [2.9] years, mean follow-up [SD] = 27.8 [6.0] years) in 1999–2017. We studied the main and interactive effects of education and BMI/dementia risk score on late-life cognition with linear regression analysis. The study design was formulated before the pre-defined analyses. RESULTS: years of education moderated the association between BMI with old-age cognition (among less educated persons, BMI-cognition association was stronger [B = −0.24 points per BMI unit, 95% CI −0.31, −0.18] than among more educated persons [B = −0.06 points per BMI unit, 95% CI −0.16, 0.03], P(interaction) < 0.01). There was a similar moderating effect of education on dementia risk score consisting of cardiovascular risk factors (P < 0.001). CONCLUSIONS: our results support the cognitive reserve hypothesis. Those with higher education may tolerate the deteriorative effects of midlife cardiovascular risk factors on old-age cognition better than those with lower education.
format Online
Article
Text
id pubmed-8824709
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-88247092022-02-09 Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study Iso-Markku, Paula Kaprio, Jaakko Lindgrén, Noora Rinne, Juha O Vuoksimaa, Eero Age Ageing Research Paper BACKGROUND: higher educational attainment and less midlife cardiovascular risk factors are related to better old-age cognition. Whether education moderates the association between cardiovascular risk factors and late-life cognition is not known. We studied if higher education provides resilience against the deteriorative effects of higher middle-age body mass index (BMI) and a combination of midlife cardiovascular risk factors on old-age cognition. METHODS: the study population is the older Finnish Twin Cohort (n = 4,051, mean age [standard deviation, SD] = 45.5 years [6.5]). Cardiovascular risk factors and education were studied at baseline with questionnaires in 1975, 1981 and/or 1990 (participation rates of 89, 84 and 77%, respectively). Cognition was evaluated with telephone interviews (participation rate 67%, mean age [SD] =73.4 [2.9] years, mean follow-up [SD] = 27.8 [6.0] years) in 1999–2017. We studied the main and interactive effects of education and BMI/dementia risk score on late-life cognition with linear regression analysis. The study design was formulated before the pre-defined analyses. RESULTS: years of education moderated the association between BMI with old-age cognition (among less educated persons, BMI-cognition association was stronger [B = −0.24 points per BMI unit, 95% CI −0.31, −0.18] than among more educated persons [B = −0.06 points per BMI unit, 95% CI −0.16, 0.03], P(interaction) < 0.01). There was a similar moderating effect of education on dementia risk score consisting of cardiovascular risk factors (P < 0.001). CONCLUSIONS: our results support the cognitive reserve hypothesis. Those with higher education may tolerate the deteriorative effects of midlife cardiovascular risk factors on old-age cognition better than those with lower education. Oxford University Press 2022-02-02 /pmc/articles/PMC8824709/ /pubmed/35134847 http://dx.doi.org/10.1093/ageing/afab228 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the British Geriatrics Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Iso-Markku, Paula
Kaprio, Jaakko
Lindgrén, Noora
Rinne, Juha O
Vuoksimaa, Eero
Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title_full Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title_fullStr Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title_full_unstemmed Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title_short Education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
title_sort education as a moderator of middle-age cardiovascular risk factor—old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824709/
https://www.ncbi.nlm.nih.gov/pubmed/35134847
http://dx.doi.org/10.1093/ageing/afab228
work_keys_str_mv AT isomarkkupaula educationasamoderatorofmiddleagecardiovascularriskfactoroldagecognitionrelationshipstestingcognitivereservehypothesisinepidemiologicalstudy
AT kapriojaakko educationasamoderatorofmiddleagecardiovascularriskfactoroldagecognitionrelationshipstestingcognitivereservehypothesisinepidemiologicalstudy
AT lindgrennoora educationasamoderatorofmiddleagecardiovascularriskfactoroldagecognitionrelationshipstestingcognitivereservehypothesisinepidemiologicalstudy
AT rinnejuhao educationasamoderatorofmiddleagecardiovascularriskfactoroldagecognitionrelationshipstestingcognitivereservehypothesisinepidemiologicalstudy
AT vuoksimaaeero educationasamoderatorofmiddleagecardiovascularriskfactoroldagecognitionrelationshipstestingcognitivereservehypothesisinepidemiologicalstudy