The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients

Polymorphisms of Fcγ receptors have been associated with variable responses to infections. We determined the association of functional polymorphisms rs1801274 in the FCGR2A and rs396991 in the FCGR3A with COVID-19 severity. This study involved 453 patients with severe COVID-19, in which the FCGR2A r...

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Autores principales: López-Martínez, Rocío, Albaiceta, Guillermo M., Amado-Rodríguez, Laura, Cuesta-Llavona, Elías, Gómez, Juan, García-Clemente, Marta, Vázquez-Coto, Daniel, Alvarez, Victoria, Coto, Eliecer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824710/
https://www.ncbi.nlm.nih.gov/pubmed/35149195
http://dx.doi.org/10.1016/j.clim.2022.108954
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author López-Martínez, Rocío
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
Cuesta-Llavona, Elías
Gómez, Juan
García-Clemente, Marta
Vázquez-Coto, Daniel
Alvarez, Victoria
Coto, Eliecer
author_facet López-Martínez, Rocío
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
Cuesta-Llavona, Elías
Gómez, Juan
García-Clemente, Marta
Vázquez-Coto, Daniel
Alvarez, Victoria
Coto, Eliecer
author_sort López-Martínez, Rocío
collection PubMed
description Polymorphisms of Fcγ receptors have been associated with variable responses to infections. We determined the association of functional polymorphisms rs1801274 in the FCGR2A and rs396991 in the FCGR3A with COVID-19 severity. This study involved 453 patients with severe COVID-19, in which the FCGR2A rs1801274 G-allele (131-Arg) was significantly associated with death (p = 0.02, OR = 1.47). This effect was independent of age and increased IL6 and D-Dimer levels. This study suggests that the FCGR2A gene might be associated with the risk of death among COVID-19 patients. Our study has several limitations, mainly the limited number of patients and the inclusion of a single population. It is thus necessary to confirm this result in larger cohorts from different populations.
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spelling pubmed-88247102022-02-09 The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients López-Martínez, Rocío Albaiceta, Guillermo M. Amado-Rodríguez, Laura Cuesta-Llavona, Elías Gómez, Juan García-Clemente, Marta Vázquez-Coto, Daniel Alvarez, Victoria Coto, Eliecer Clin Immunol Article Polymorphisms of Fcγ receptors have been associated with variable responses to infections. We determined the association of functional polymorphisms rs1801274 in the FCGR2A and rs396991 in the FCGR3A with COVID-19 severity. This study involved 453 patients with severe COVID-19, in which the FCGR2A rs1801274 G-allele (131-Arg) was significantly associated with death (p = 0.02, OR = 1.47). This effect was independent of age and increased IL6 and D-Dimer levels. This study suggests that the FCGR2A gene might be associated with the risk of death among COVID-19 patients. Our study has several limitations, mainly the limited number of patients and the inclusion of a single population. It is thus necessary to confirm this result in larger cohorts from different populations. Elsevier Inc. 2022-03 2022-02-09 /pmc/articles/PMC8824710/ /pubmed/35149195 http://dx.doi.org/10.1016/j.clim.2022.108954 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
López-Martínez, Rocío
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
Cuesta-Llavona, Elías
Gómez, Juan
García-Clemente, Marta
Vázquez-Coto, Daniel
Alvarez, Victoria
Coto, Eliecer
The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title_full The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title_fullStr The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title_full_unstemmed The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title_short The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients
title_sort fcgr2a rs1801274 polymorphism was associated with the risk of death among covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824710/
https://www.ncbi.nlm.nih.gov/pubmed/35149195
http://dx.doi.org/10.1016/j.clim.2022.108954
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