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Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia

PURPOSE: Histidine-rich glycoprotein (HRG) is abundant in serum and has been implicated in several processes including blood coagulation and immune response. This prospective study is aimed at exploring HRG as a biomarker in patients hospitalized for community-acquired pneumonia (CAP). METHODS: A to...

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Autores principales: He, Xinwei, Luo, Qiongzhen, Zhao, Lili, Shang, Ying, Gao, Zhancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824745/
https://www.ncbi.nlm.nih.gov/pubmed/35154511
http://dx.doi.org/10.1155/2022/4713045
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author He, Xinwei
Luo, Qiongzhen
Zhao, Lili
Shang, Ying
Gao, Zhancheng
author_facet He, Xinwei
Luo, Qiongzhen
Zhao, Lili
Shang, Ying
Gao, Zhancheng
author_sort He, Xinwei
collection PubMed
description PURPOSE: Histidine-rich glycoprotein (HRG) is abundant in serum and has been implicated in several processes including blood coagulation and immune response. This prospective study is aimed at exploring HRG as a biomarker in patients hospitalized for community-acquired pneumonia (CAP). METHODS: A total of 160 patients (73 severe CAP, 57 nonsevere CAP), and 30 healthy controls were enrolled in 2019. Demographic and clinical data were recorded for all patients. Serum HRG concentration was measured upon admission using ELISA. RESULTS: HRG levels were significantly lower in severe CAP patients compared with other groups, regardless of etiology, and were negatively correlated with serum interleukin-6 and disease severity index scores. Combination of CURB-65, PSI, and APACHE II scores with HRG values significantly improved the accuracy of predicting 30-day mortality in these patients. Cox regression analysis showed that HRG could serve as an independent risk factor for 30-day mortality. Notably, patients with HRG ≤ 16.92 μg/mL had significantly lower cumulative survival than those with HRG > 16.92 μg/mL. CONCLUSION: Serum HRG levels are lower in patients with severe CAP and are negatively correlated with disease severity scores. Measurement of HRG upon admission can provide valuable prognostic information for patients with CAP.
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spelling pubmed-88247452022-02-10 Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia He, Xinwei Luo, Qiongzhen Zhao, Lili Shang, Ying Gao, Zhancheng Dis Markers Research Article PURPOSE: Histidine-rich glycoprotein (HRG) is abundant in serum and has been implicated in several processes including blood coagulation and immune response. This prospective study is aimed at exploring HRG as a biomarker in patients hospitalized for community-acquired pneumonia (CAP). METHODS: A total of 160 patients (73 severe CAP, 57 nonsevere CAP), and 30 healthy controls were enrolled in 2019. Demographic and clinical data were recorded for all patients. Serum HRG concentration was measured upon admission using ELISA. RESULTS: HRG levels were significantly lower in severe CAP patients compared with other groups, regardless of etiology, and were negatively correlated with serum interleukin-6 and disease severity index scores. Combination of CURB-65, PSI, and APACHE II scores with HRG values significantly improved the accuracy of predicting 30-day mortality in these patients. Cox regression analysis showed that HRG could serve as an independent risk factor for 30-day mortality. Notably, patients with HRG ≤ 16.92 μg/mL had significantly lower cumulative survival than those with HRG > 16.92 μg/mL. CONCLUSION: Serum HRG levels are lower in patients with severe CAP and are negatively correlated with disease severity scores. Measurement of HRG upon admission can provide valuable prognostic information for patients with CAP. Hindawi 2022-02-01 /pmc/articles/PMC8824745/ /pubmed/35154511 http://dx.doi.org/10.1155/2022/4713045 Text en Copyright © 2022 Xinwei He et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
He, Xinwei
Luo, Qiongzhen
Zhao, Lili
Shang, Ying
Gao, Zhancheng
Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title_full Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title_fullStr Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title_full_unstemmed Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title_short Prognostic Value of Histidine-Rich Glycoprotein for Community-Acquired Pneumonia
title_sort prognostic value of histidine-rich glycoprotein for community-acquired pneumonia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824745/
https://www.ncbi.nlm.nih.gov/pubmed/35154511
http://dx.doi.org/10.1155/2022/4713045
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