Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3

We present a case of life-threatening refractory hypertension (rHTN) in a patient with stage 3b chronic kidney disease that was unresponsive to open surgical renal denervation (RDN) but responded to bilateral nephrectomy (BLN). Both RDN and BLN reduce the increased sympathetic activation in rHTN. Ho...

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Autores principales: Zemke, Anna M, Rodby, Roger A, Hertl, Martin, Waleed, Ali, Bakris, George L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824767/
https://www.ncbi.nlm.nih.gov/pubmed/35145649
http://dx.doi.org/10.1093/ckj/sfab179
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author Zemke, Anna M
Rodby, Roger A
Hertl, Martin
Waleed, Ali
Bakris, George L
author_facet Zemke, Anna M
Rodby, Roger A
Hertl, Martin
Waleed, Ali
Bakris, George L
author_sort Zemke, Anna M
collection PubMed
description We present a case of life-threatening refractory hypertension (rHTN) in a patient with stage 3b chronic kidney disease that was unresponsive to open surgical renal denervation (RDN) but responded to bilateral nephrectomy (BLN). Both RDN and BLN reduce the increased sympathetic activation in rHTN. However, RDN has yet to show reductions in blood pressure adequate for the average patient with rHTN, and BLN has thus far been reserved for patients with preexisting end-stage kidney disease (ESKD). Our case suggests that there are patients with rHTN that warrant consideration of BLN prior to developing ESKD.
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spelling pubmed-88247672022-02-09 Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3 Zemke, Anna M Rodby, Roger A Hertl, Martin Waleed, Ali Bakris, George L Clin Kidney J Exceptional Case We present a case of life-threatening refractory hypertension (rHTN) in a patient with stage 3b chronic kidney disease that was unresponsive to open surgical renal denervation (RDN) but responded to bilateral nephrectomy (BLN). Both RDN and BLN reduce the increased sympathetic activation in rHTN. However, RDN has yet to show reductions in blood pressure adequate for the average patient with rHTN, and BLN has thus far been reserved for patients with preexisting end-stage kidney disease (ESKD). Our case suggests that there are patients with rHTN that warrant consideration of BLN prior to developing ESKD. Oxford University Press 2021-09-28 /pmc/articles/PMC8824767/ /pubmed/35145649 http://dx.doi.org/10.1093/ckj/sfab179 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Case
Zemke, Anna M
Rodby, Roger A
Hertl, Martin
Waleed, Ali
Bakris, George L
Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title_full Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title_fullStr Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title_full_unstemmed Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title_short Successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
title_sort successful treatment of refractory hypertension with bilateral nephrectomy in a patient with chronic kidney disease stage 3
topic Exceptional Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824767/
https://www.ncbi.nlm.nih.gov/pubmed/35145649
http://dx.doi.org/10.1093/ckj/sfab179
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