Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma

A 42-year-old man with smoldering immunoglobulin G kappa multiple myeloma showed a heavy proteinuria composed of free light chain, prompting performance of a kidney biopsy. Electron microscopy revealed numerous rhomboid-shaped crystals labelled by the anti-kappa in immunogold, notably in the cytopla...

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Autores principales: Eymieux, Sébastien, Miquelestorena-Standley, Elodie, Rabot, Nolwenn, Maisons, Valentin, Touchard, Guy, Blanchard, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824780/
https://www.ncbi.nlm.nih.gov/pubmed/35145650
http://dx.doi.org/10.1093/ckj/sfab197
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author Eymieux, Sébastien
Miquelestorena-Standley, Elodie
Rabot, Nolwenn
Maisons, Valentin
Touchard, Guy
Blanchard, Emmanuelle
author_facet Eymieux, Sébastien
Miquelestorena-Standley, Elodie
Rabot, Nolwenn
Maisons, Valentin
Touchard, Guy
Blanchard, Emmanuelle
author_sort Eymieux, Sébastien
collection PubMed
description A 42-year-old man with smoldering immunoglobulin G kappa multiple myeloma showed a heavy proteinuria composed of free light chain, prompting performance of a kidney biopsy. Electron microscopy revealed numerous rhomboid-shaped crystals labelled by the anti-kappa in immunogold, notably in the cytoplasm of podocytes, establishing the diagnosis of crystalline podocytopathy. This case illustrates a rare form of monoclonal gammopathy of renal significance, and highlights the key role of electron microscopy and immunogold to better elucidate the location and composition of crystals.
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spelling pubmed-88247802022-02-09 Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma Eymieux, Sébastien Miquelestorena-Standley, Elodie Rabot, Nolwenn Maisons, Valentin Touchard, Guy Blanchard, Emmanuelle Clin Kidney J Exceptional Case A 42-year-old man with smoldering immunoglobulin G kappa multiple myeloma showed a heavy proteinuria composed of free light chain, prompting performance of a kidney biopsy. Electron microscopy revealed numerous rhomboid-shaped crystals labelled by the anti-kappa in immunogold, notably in the cytoplasm of podocytes, establishing the diagnosis of crystalline podocytopathy. This case illustrates a rare form of monoclonal gammopathy of renal significance, and highlights the key role of electron microscopy and immunogold to better elucidate the location and composition of crystals. Oxford University Press 2021-10-06 /pmc/articles/PMC8824780/ /pubmed/35145650 http://dx.doi.org/10.1093/ckj/sfab197 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Case
Eymieux, Sébastien
Miquelestorena-Standley, Elodie
Rabot, Nolwenn
Maisons, Valentin
Touchard, Guy
Blanchard, Emmanuelle
Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title_full Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title_fullStr Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title_full_unstemmed Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title_short Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
title_sort crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
topic Exceptional Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824780/
https://www.ncbi.nlm.nih.gov/pubmed/35145650
http://dx.doi.org/10.1093/ckj/sfab197
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