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Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations

Previous guidelines for the treatment of people with type 2 diabetes mellitus (T2D) have relied heavily upon rigid algorithms for the sequential addition of pharmacotherapies to achieve target glycemic control. More recent guidelines advocate a personalized approach for diabetes treatment, to improv...

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Autores principales: Williams, David M, Jones, Hannah, Stephens, Jeffrey W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824792/
https://www.ncbi.nlm.nih.gov/pubmed/35153495
http://dx.doi.org/10.2147/DMSO.S331654
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author Williams, David M
Jones, Hannah
Stephens, Jeffrey W
author_facet Williams, David M
Jones, Hannah
Stephens, Jeffrey W
author_sort Williams, David M
collection PubMed
description Previous guidelines for the treatment of people with type 2 diabetes mellitus (T2D) have relied heavily upon rigid algorithms for the sequential addition of pharmacotherapies to achieve target glycemic control. More recent guidelines advocate a personalized approach for diabetes treatment, to improve patient satisfaction, quality of life, medication adherence and overall health outcomes. Clinicians should work with patients to develop personalized goals for their treatment, including targeted glycemic control, weight management, prevention and treatment of associated comorbidities and avoidance of complications such as hypoglycemia. Factors that affect the intensity of treatment and choice of pharmacotherapy should include medical and patient influences. Medical considerations include the diabetes phenotype, biomarkers including genetic tests, and the presence of comorbidities such as cardiovascular, renal, or hepatic disease. Patient factors include their treatment preference, age and life expectancy, diabetes duration, hypoglycemia fear and unawareness, psychological and social circumstances. The use of a personalized approach in the management of people with T2D can reduce the cost and failure associated with the algorithmic “one-size-fits-all” approach, to anticipate disease progression, improve the response to diabetes pharmacotherapy and reduce the incidence of diabetes-associated complications. Ultimately, the use of personalized medicine in people with T2D should improve medication adherence, patient satisfaction and quality of life to reduce diabetes distress and improve physical health outcomes.
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spelling pubmed-88247922022-02-10 Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations Williams, David M Jones, Hannah Stephens, Jeffrey W Diabetes Metab Syndr Obes Review Previous guidelines for the treatment of people with type 2 diabetes mellitus (T2D) have relied heavily upon rigid algorithms for the sequential addition of pharmacotherapies to achieve target glycemic control. More recent guidelines advocate a personalized approach for diabetes treatment, to improve patient satisfaction, quality of life, medication adherence and overall health outcomes. Clinicians should work with patients to develop personalized goals for their treatment, including targeted glycemic control, weight management, prevention and treatment of associated comorbidities and avoidance of complications such as hypoglycemia. Factors that affect the intensity of treatment and choice of pharmacotherapy should include medical and patient influences. Medical considerations include the diabetes phenotype, biomarkers including genetic tests, and the presence of comorbidities such as cardiovascular, renal, or hepatic disease. Patient factors include their treatment preference, age and life expectancy, diabetes duration, hypoglycemia fear and unawareness, psychological and social circumstances. The use of a personalized approach in the management of people with T2D can reduce the cost and failure associated with the algorithmic “one-size-fits-all” approach, to anticipate disease progression, improve the response to diabetes pharmacotherapy and reduce the incidence of diabetes-associated complications. Ultimately, the use of personalized medicine in people with T2D should improve medication adherence, patient satisfaction and quality of life to reduce diabetes distress and improve physical health outcomes. Dove 2022-02-04 /pmc/articles/PMC8824792/ /pubmed/35153495 http://dx.doi.org/10.2147/DMSO.S331654 Text en © 2022 Williams et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Williams, David M
Jones, Hannah
Stephens, Jeffrey W
Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title_full Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title_fullStr Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title_full_unstemmed Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title_short Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
title_sort personalized type 2 diabetes management: an update on recent advances and recommendations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824792/
https://www.ncbi.nlm.nih.gov/pubmed/35153495
http://dx.doi.org/10.2147/DMSO.S331654
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