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Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma

OTUD7B is a deubiquitinase and has been reported as a prognostic factor in various solid tumors. However, its prognostic value in lymphoma patients remains unclear. We detected OTUD7B expression levels in 160 diffuse large B-cell lymphoma (DLBCL) tissue samples by immunohistochemistry, and analyzed...

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Autores principales: Qiu, Shi, Liu, Yizhen, Gui, Ailing, Xia, Zuguang, Liu, Wen, Gu, Juan J., Zuo, Ji, Yang, Ling, Zhang, Qunling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824891/
https://www.ncbi.nlm.nih.gov/pubmed/35154465
http://dx.doi.org/10.7150/jca.65835
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author Qiu, Shi
Liu, Yizhen
Gui, Ailing
Xia, Zuguang
Liu, Wen
Gu, Juan J.
Zuo, Ji
Yang, Ling
Zhang, Qunling
author_facet Qiu, Shi
Liu, Yizhen
Gui, Ailing
Xia, Zuguang
Liu, Wen
Gu, Juan J.
Zuo, Ji
Yang, Ling
Zhang, Qunling
author_sort Qiu, Shi
collection PubMed
description OTUD7B is a deubiquitinase and has been reported as a prognostic factor in various solid tumors. However, its prognostic value in lymphoma patients remains unclear. We detected OTUD7B expression levels in 160 diffuse large B-cell lymphoma (DLBCL) tissue samples by immunohistochemistry, and analyzed correlations between its expression and clinic-pathologic parameters as well as clinical outcomes. We also investigated association between OTUD7B expression and chemotherapeutic drugs anti-tumor activity in vitro. We found that OTUD7B overexpressed in 129 (80.6%) cases, and patients with overexpression of OTUD7B experienced better overall survival comparing to those with OTUD7B low expression (P=0.021). Multivariate Cox regression analysis illustrated that OTUD7B was an independent prognostic indicator. In DLBCL cell lines, we found that Chidamide could up-regulate OTUD7B in several DLBCL cell lines, and also had synergistic effect with doxorubicin at low concentration. Our data illustrated that OTUD7B deficiency is a negative predictor of clinical outcome, and might be a potential therapeutic target in the treatment of diffuse large B-cell lymphoma.
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spelling pubmed-88248912022-02-11 Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma Qiu, Shi Liu, Yizhen Gui, Ailing Xia, Zuguang Liu, Wen Gu, Juan J. Zuo, Ji Yang, Ling Zhang, Qunling J Cancer Research Paper OTUD7B is a deubiquitinase and has been reported as a prognostic factor in various solid tumors. However, its prognostic value in lymphoma patients remains unclear. We detected OTUD7B expression levels in 160 diffuse large B-cell lymphoma (DLBCL) tissue samples by immunohistochemistry, and analyzed correlations between its expression and clinic-pathologic parameters as well as clinical outcomes. We also investigated association between OTUD7B expression and chemotherapeutic drugs anti-tumor activity in vitro. We found that OTUD7B overexpressed in 129 (80.6%) cases, and patients with overexpression of OTUD7B experienced better overall survival comparing to those with OTUD7B low expression (P=0.021). Multivariate Cox regression analysis illustrated that OTUD7B was an independent prognostic indicator. In DLBCL cell lines, we found that Chidamide could up-regulate OTUD7B in several DLBCL cell lines, and also had synergistic effect with doxorubicin at low concentration. Our data illustrated that OTUD7B deficiency is a negative predictor of clinical outcome, and might be a potential therapeutic target in the treatment of diffuse large B-cell lymphoma. Ivyspring International Publisher 2022-01-04 /pmc/articles/PMC8824891/ /pubmed/35154465 http://dx.doi.org/10.7150/jca.65835 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Qiu, Shi
Liu, Yizhen
Gui, Ailing
Xia, Zuguang
Liu, Wen
Gu, Juan J.
Zuo, Ji
Yang, Ling
Zhang, Qunling
Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title_full Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title_fullStr Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title_full_unstemmed Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title_short Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
title_sort deubiquitinase otud7b is a potential prognostic biomarker in diffuse large b-cell lymphoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824891/
https://www.ncbi.nlm.nih.gov/pubmed/35154465
http://dx.doi.org/10.7150/jca.65835
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