Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level

The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain tissues to reveal new AD-related protein co-expression modules that were highly preserved across cohorts and brain regio...

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Detalles Bibliográficos
Autores principales: Johnson, Erik C. B., Carter, E. Kathleen, Dammer, Eric B., Duong, Duc M., Gerasimov, Ekaterina S., Liu, Yue, Liu, Jiaqi, Betarbet, Ranjita, Ping, Lingyan, Yin, Luming, Serrano, Geidy E., Beach, Thomas G., Peng, Junmin, De Jager, Philip L., Haroutunian, Vahram, Zhang, Bin, Gaiteri, Chris, Bennett, David A., Gearing, Marla, Wingo, Thomas S., Wingo, Aliza P., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825285/
https://www.ncbi.nlm.nih.gov/pubmed/35115731
http://dx.doi.org/10.1038/s41593-021-00999-y

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