Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current COVID-19 vaccines administered intramuscularly and designed to only target the spike protein. There is a pressing need to develop next-generation vaccine strategies for broader and long-lasting protection. Using...

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Detalles Bibliográficos
Autores principales: Afkhami, Sam, D’Agostino, Michael R., Zhang, Ali, Stacey, Hannah D., Marzok, Art, Kang, Alisha, Singh, Ramandeep, Bavananthasivam, Jegarubee, Ye, Gluke, Luo, Xiangqian, Wang, Fuan, Ang, Jann C., Zganiacz, Anna, Sankar, Uma, Kazhdan, Natallia, Koenig, Joshua F.E., Phelps, Allyssa, Gameiro, Steven F., Tang, Shangguo, Jordana, Manel, Wan, Yonghong, Mossman, Karen L., Jeyanathan, Mangalakumari, Gillgrass, Amy, Medina, Maria Fe C., Smaill, Fiona, Lichty, Brian D., Miller, Matthew S., Xing, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825346/
https://www.ncbi.nlm.nih.gov/pubmed/35180381
http://dx.doi.org/10.1016/j.cell.2022.02.005

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