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Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing

Expanded CAG/CTG repeat disorders affect over 1 in 2500 individuals worldwide. Potential therapeutic avenues include gene silencing and modulation of repeat instability. However, there are major mechanistic gaps in our understanding of these processes, which prevent the rational design of an efficie...

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Detalles Bibliográficos
Autores principales:	Yang, Bin, Borgeaud, Alicia C, Buřičová, Marcela, Aeschbach, Lorène, Rodríguez-Lima, Oscar, Ruiz Buendía, Gustavo A, Cinesi, Cinzia, Taylor, Alysha S, Baubec, Tuncay, Dion, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825355/ https://www.ncbi.nlm.nih.gov/pubmed/34494094 http://dx.doi.org/10.1093/hmg/ddab255

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