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What do cellular responses to acidity tell us about cancer?
The notion that invasive cancer is a product of somatic evolution is a well-established theory that can be modelled mathematically and demonstrated empirically from therapeutic responses. Somatic evolution is by no means deterministic, and ample opportunities exist to steer its trajectory towards ca...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825410/ https://www.ncbi.nlm.nih.gov/pubmed/34850320 http://dx.doi.org/10.1007/s10555-021-10005-3 |
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author | Blaszczak, Wiktoria Swietach, Pawel |
author_facet | Blaszczak, Wiktoria Swietach, Pawel |
author_sort | Blaszczak, Wiktoria |
collection | PubMed |
description | The notion that invasive cancer is a product of somatic evolution is a well-established theory that can be modelled mathematically and demonstrated empirically from therapeutic responses. Somatic evolution is by no means deterministic, and ample opportunities exist to steer its trajectory towards cancer cell extinction. One such strategy is to alter the chemical microenvironment shared between host and cancer cells in a way that no longer favours the latter. Ever since the first description of the Warburg effect, acidosis has been recognised as a key chemical signature of the tumour microenvironment. Recent findings have suggested that responses to acidosis, arising through a process of selection and adaptation, give cancer cells a competitive advantage over the host. A surge of research efforts has attempted to understand the basis of this advantage and seek ways of exploiting it therapeutically. Here, we review key findings and place these in the context of a mathematical framework. Looking ahead, we highlight areas relating to cellular adaptation, selection, and heterogeneity that merit more research efforts in order to close in on the goal of exploiting tumour acidity in future therapies. |
format | Online Article Text |
id | pubmed-8825410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-88254102022-02-23 What do cellular responses to acidity tell us about cancer? Blaszczak, Wiktoria Swietach, Pawel Cancer Metastasis Rev Article The notion that invasive cancer is a product of somatic evolution is a well-established theory that can be modelled mathematically and demonstrated empirically from therapeutic responses. Somatic evolution is by no means deterministic, and ample opportunities exist to steer its trajectory towards cancer cell extinction. One such strategy is to alter the chemical microenvironment shared between host and cancer cells in a way that no longer favours the latter. Ever since the first description of the Warburg effect, acidosis has been recognised as a key chemical signature of the tumour microenvironment. Recent findings have suggested that responses to acidosis, arising through a process of selection and adaptation, give cancer cells a competitive advantage over the host. A surge of research efforts has attempted to understand the basis of this advantage and seek ways of exploiting it therapeutically. Here, we review key findings and place these in the context of a mathematical framework. Looking ahead, we highlight areas relating to cellular adaptation, selection, and heterogeneity that merit more research efforts in order to close in on the goal of exploiting tumour acidity in future therapies. Springer US 2021-11-30 2021 /pmc/articles/PMC8825410/ /pubmed/34850320 http://dx.doi.org/10.1007/s10555-021-10005-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Blaszczak, Wiktoria Swietach, Pawel What do cellular responses to acidity tell us about cancer? |
title | What do cellular responses to acidity tell us about cancer? |
title_full | What do cellular responses to acidity tell us about cancer? |
title_fullStr | What do cellular responses to acidity tell us about cancer? |
title_full_unstemmed | What do cellular responses to acidity tell us about cancer? |
title_short | What do cellular responses to acidity tell us about cancer? |
title_sort | what do cellular responses to acidity tell us about cancer? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825410/ https://www.ncbi.nlm.nih.gov/pubmed/34850320 http://dx.doi.org/10.1007/s10555-021-10005-3 |
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