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Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up
PURPOSE: Endovascular coil occlusion is a successful and rapidly evolving strategy used to treat patients who present with intracranial aneurysms. This study aimed to compare the safety and efficacy of the Avenir® and Axium(TM) passive mechanically detachable coil systems. METHODS: A prospective, mu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825471/ https://www.ncbi.nlm.nih.gov/pubmed/35153992 http://dx.doi.org/10.3389/fneur.2021.817989 |
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author | Li, Wei Ye, Ming Cimpoca, Alexandru Henkes, Hans Wang, Honglei Xu, Xiang Gu, Yuxiang Shi, Huaizhang Ji, Hongming Wang, Feng Zhao, Yuanli Guo, Geng Zhang, Hongqi Li, Youxiang |
author_facet | Li, Wei Ye, Ming Cimpoca, Alexandru Henkes, Hans Wang, Honglei Xu, Xiang Gu, Yuxiang Shi, Huaizhang Ji, Hongming Wang, Feng Zhao, Yuanli Guo, Geng Zhang, Hongqi Li, Youxiang |
author_sort | Li, Wei |
collection | PubMed |
description | PURPOSE: Endovascular coil occlusion is a successful and rapidly evolving strategy used to treat patients who present with intracranial aneurysms. This study aimed to compare the safety and efficacy of the Avenir® and Axium(TM) passive mechanically detachable coil systems. METHODS: A prospective, multicenter, randomized controlled study was carried out at ten medical centers from March 2018 to December 2019. A series of consecutive patients diagnosed with intracranial aneurysms were randomly assigned to undergo endovascular treatment with either the Avenir® or the Axium(TM) mechanically detachable coil systems. The short-term outcomes from the two groups were compared with a focus on treatment efficacy and safety. RESULTS: A total of 162 and 161 patients were enrolled in the Avenir and Axium groups, respectively. The rate of successful coil detachment was 100% for the Avenir group and 99.38% for the Axium group. At the six-month follow-up visit, the overall aneurysm occlusion rate was 94.66% for the Avenir group and 96.95% for the Axium group (p > 0.05). We observed no statistically significant differences in clinical condition (as per the modified Rankin Scale) or the degree of aneurysm occlusion (as determined by digital subtraction angiography [DSA] and Raymond-Roy Occlusion Classification). Surgical complications were reported in 27 subjects in the Avenir group and 22 in the Axium group (p > 0.05). DSA performed at 6 months revealed complete aneurysm occlusion in 84 and 86% of patients in the Avenir and Axium groups, respectively. CONCLUSION: We observed no significant short-term differences with respect to efficacy or safety when using either Avenir® or Axium(TM) coils for the treatment of intracranial aneurysms. |
format | Online Article Text |
id | pubmed-8825471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88254712022-02-10 Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up Li, Wei Ye, Ming Cimpoca, Alexandru Henkes, Hans Wang, Honglei Xu, Xiang Gu, Yuxiang Shi, Huaizhang Ji, Hongming Wang, Feng Zhao, Yuanli Guo, Geng Zhang, Hongqi Li, Youxiang Front Neurol Neurology PURPOSE: Endovascular coil occlusion is a successful and rapidly evolving strategy used to treat patients who present with intracranial aneurysms. This study aimed to compare the safety and efficacy of the Avenir® and Axium(TM) passive mechanically detachable coil systems. METHODS: A prospective, multicenter, randomized controlled study was carried out at ten medical centers from March 2018 to December 2019. A series of consecutive patients diagnosed with intracranial aneurysms were randomly assigned to undergo endovascular treatment with either the Avenir® or the Axium(TM) mechanically detachable coil systems. The short-term outcomes from the two groups were compared with a focus on treatment efficacy and safety. RESULTS: A total of 162 and 161 patients were enrolled in the Avenir and Axium groups, respectively. The rate of successful coil detachment was 100% for the Avenir group and 99.38% for the Axium group. At the six-month follow-up visit, the overall aneurysm occlusion rate was 94.66% for the Avenir group and 96.95% for the Axium group (p > 0.05). We observed no statistically significant differences in clinical condition (as per the modified Rankin Scale) or the degree of aneurysm occlusion (as determined by digital subtraction angiography [DSA] and Raymond-Roy Occlusion Classification). Surgical complications were reported in 27 subjects in the Avenir group and 22 in the Axium group (p > 0.05). DSA performed at 6 months revealed complete aneurysm occlusion in 84 and 86% of patients in the Avenir and Axium groups, respectively. CONCLUSION: We observed no significant short-term differences with respect to efficacy or safety when using either Avenir® or Axium(TM) coils for the treatment of intracranial aneurysms. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8825471/ /pubmed/35153992 http://dx.doi.org/10.3389/fneur.2021.817989 Text en Copyright © 2022 Li, Ye, Cimpoca, Henkes, Wang, Xu, Gu, Shi, Ji, Wang, Zhao, Guo, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Li, Wei Ye, Ming Cimpoca, Alexandru Henkes, Hans Wang, Honglei Xu, Xiang Gu, Yuxiang Shi, Huaizhang Ji, Hongming Wang, Feng Zhao, Yuanli Guo, Geng Zhang, Hongqi Li, Youxiang Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title | Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title_full | Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title_fullStr | Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title_full_unstemmed | Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title_short | Avenir® vs. Axium(TM) Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up |
title_sort | avenir® vs. axium(tm) coils for the treatment of intracranial aneurysms: results of a multicenter randomized controlled trial with short-term follow-up |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825471/ https://www.ncbi.nlm.nih.gov/pubmed/35153992 http://dx.doi.org/10.3389/fneur.2021.817989 |
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