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Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination...

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Autores principales: Wang, Wei, Balfe, Peter, Eyre, David W., Lumley, Sheila F., O’Donnell, Denise, Warren, Fiona, Crook, Derrick W., Jeffery, Katie, Matthews, Philippa C., Klerman, Elizabeth B., McKeating, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825702/
https://www.ncbi.nlm.nih.gov/pubmed/34866459
http://dx.doi.org/10.1177/07487304211059315
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author Wang, Wei
Balfe, Peter
Eyre, David W.
Lumley, Sheila F.
O’Donnell, Denise
Warren, Fiona
Crook, Derrick W.
Jeffery, Katie
Matthews, Philippa C.
Klerman, Elizabeth B.
McKeating, Jane A.
author_facet Wang, Wei
Balfe, Peter
Eyre, David W.
Lumley, Sheila F.
O’Donnell, Denise
Warren, Fiona
Crook, Derrick W.
Jeffery, Katie
Matthews, Philippa C.
Klerman, Elizabeth B.
McKeating, Jane A.
author_sort Wang, Wei
collection PubMed
description The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy.
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spelling pubmed-88257022022-02-09 Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers Wang, Wei Balfe, Peter Eyre, David W. Lumley, Sheila F. O’Donnell, Denise Warren, Fiona Crook, Derrick W. Jeffery, Katie Matthews, Philippa C. Klerman, Elizabeth B. McKeating, Jane A. J Biol Rhythms Letter The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy. SAGE Publications 2021-12-04 2022-02 /pmc/articles/PMC8825702/ /pubmed/34866459 http://dx.doi.org/10.1177/07487304211059315 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Letter
Wang, Wei
Balfe, Peter
Eyre, David W.
Lumley, Sheila F.
O’Donnell, Denise
Warren, Fiona
Crook, Derrick W.
Jeffery, Katie
Matthews, Philippa C.
Klerman, Elizabeth B.
McKeating, Jane A.
Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title_full Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title_fullStr Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title_full_unstemmed Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title_short Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
title_sort time of day of vaccination affects sars-cov-2 antibody responses in an observational study of health care workers
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825702/
https://www.ncbi.nlm.nih.gov/pubmed/34866459
http://dx.doi.org/10.1177/07487304211059315
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