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The Glomerulus According to the Mesangium

The glomerulus is the functional unit for filtration of blood and formation of primary urine. This intricate structure is composed of the endothelium with its glycocalyx facing the blood, the glomerular basement membrane and the podocytes facing the urinary space of Bowman's capsule. The mesang...

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Autores principales: Ebefors, Kerstin, Bergwall, Lovisa, Nyström, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825785/
https://www.ncbi.nlm.nih.gov/pubmed/35155460
http://dx.doi.org/10.3389/fmed.2021.740527
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author Ebefors, Kerstin
Bergwall, Lovisa
Nyström, Jenny
author_facet Ebefors, Kerstin
Bergwall, Lovisa
Nyström, Jenny
author_sort Ebefors, Kerstin
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description The glomerulus is the functional unit for filtration of blood and formation of primary urine. This intricate structure is composed of the endothelium with its glycocalyx facing the blood, the glomerular basement membrane and the podocytes facing the urinary space of Bowman's capsule. The mesangial cells are the central hub connecting and supporting all these structures. The components as a unit ensure a high permselectivity hindering large plasma proteins from passing into the urine while readily filtering water and small solutes. There has been a long-standing interest and discussion regarding the functional contribution of the different cellular components but the mesangial cells have been somewhat overlooked in this context. The mesangium is situated in close proximity to all other cellular components of the glomerulus and should be considered important in pathophysiological events leading to glomerular disease. This review will highlight the role of the mesangium in both glomerular function and intra-glomerular crosstalk. It also aims to explain the role of the mesangium as a central component involved in disease onset and progression as well as signaling to maintain the functions of other glomerular cells to uphold permselectivity and glomerular health.
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spelling pubmed-88257852022-02-10 The Glomerulus According to the Mesangium Ebefors, Kerstin Bergwall, Lovisa Nyström, Jenny Front Med (Lausanne) Medicine The glomerulus is the functional unit for filtration of blood and formation of primary urine. This intricate structure is composed of the endothelium with its glycocalyx facing the blood, the glomerular basement membrane and the podocytes facing the urinary space of Bowman's capsule. The mesangial cells are the central hub connecting and supporting all these structures. The components as a unit ensure a high permselectivity hindering large plasma proteins from passing into the urine while readily filtering water and small solutes. There has been a long-standing interest and discussion regarding the functional contribution of the different cellular components but the mesangial cells have been somewhat overlooked in this context. The mesangium is situated in close proximity to all other cellular components of the glomerulus and should be considered important in pathophysiological events leading to glomerular disease. This review will highlight the role of the mesangium in both glomerular function and intra-glomerular crosstalk. It also aims to explain the role of the mesangium as a central component involved in disease onset and progression as well as signaling to maintain the functions of other glomerular cells to uphold permselectivity and glomerular health. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8825785/ /pubmed/35155460 http://dx.doi.org/10.3389/fmed.2021.740527 Text en Copyright © 2022 Ebefors, Bergwall and Nyström. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ebefors, Kerstin
Bergwall, Lovisa
Nyström, Jenny
The Glomerulus According to the Mesangium
title The Glomerulus According to the Mesangium
title_full The Glomerulus According to the Mesangium
title_fullStr The Glomerulus According to the Mesangium
title_full_unstemmed The Glomerulus According to the Mesangium
title_short The Glomerulus According to the Mesangium
title_sort glomerulus according to the mesangium
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825785/
https://www.ncbi.nlm.nih.gov/pubmed/35155460
http://dx.doi.org/10.3389/fmed.2021.740527
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