In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue

Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome - mitochondrial DNA (mtDNA). Mutations in mtDNA often lead to clinically heterogeneou...

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Detalles Bibliográficos
Autores principales: Silva-Pinheiro, Pedro, Nash, Pavel A., Van Haute, Lindsey, Mutti, Christian D., Turner, Keira, Minczuk, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825850/
https://www.ncbi.nlm.nih.gov/pubmed/35136065
http://dx.doi.org/10.1038/s41467-022-28358-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825850/
https://www.ncbi.nlm.nih.gov/pubmed/35136065
http://dx.doi.org/10.1038/s41467-022-28358-w

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