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PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes

The Pleckstrin homology domain leucine-rich repeat protein phosphatases (PHLPPs) are novel therapeutic targets for the restoration of β-cell survival and function in diabetes. Their upregulation and activation in β-cells under conditions of both type 1 and type 2 diabetes directly correlates with β-...

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Detalles Bibliográficos
Autores principales:	Lupse, Blaz, Heise, Nick, Maedler, Kathrin, Ardestani, Amin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Comment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825859/ https://www.ncbi.nlm.nih.gov/pubmed/35136063 http://dx.doi.org/10.1038/s41420-022-00853-5

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