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No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis
OBJECTIVES: Periodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825874/ https://www.ncbi.nlm.nih.gov/pubmed/35154127 http://dx.doi.org/10.3389/fimmu.2022.808832 |
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author | Yin, Kang-Jia Huang, Ji-Xiang Wang, Peng Yang, Xiao-Ke Tao, Sha-Sha Li, Hong-Miao Ni, Jing Pan, Hai-Feng |
author_facet | Yin, Kang-Jia Huang, Ji-Xiang Wang, Peng Yang, Xiao-Ke Tao, Sha-Sha Li, Hong-Miao Ni, Jing Pan, Hai-Feng |
author_sort | Yin, Kang-Jia |
collection | PubMed |
description | OBJECTIVES: Periodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of PD with arthritis, including rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS: We performed a two-sample bidirectional Mendelian randomization (MR) analysis using publicly released genome-wide association studies (GWAS) statistics. The inverse-variance weighted (IVW) method was used as the primary analysis. We applied four complementary methods, including weighted median, weighted mode, MR-Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) to detect and correct for the effect of horizontal pleiotropy. RESULTS: Genetically determined PD did not have a causal effect on OA (OR = 1.06, 95% CI: 0.99-1.15, P = 0.09) and RA (OR = 0.99, 95% CI: 0.87-1.13, P = 0.89). Furthermore, we did not find a significant causal effect of arthritis on PD in the reverse MR analysis. The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. Horizontal pleiotropy was unlikely to distort the causal estimates according to the sensitivity analysis. CONCLUSIONS: Our MR analysis reveals non-causal association of PD with arthritis, despite observational studies reporting an association between PD and arthritis. |
format | Online Article Text |
id | pubmed-8825874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88258742022-02-10 No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis Yin, Kang-Jia Huang, Ji-Xiang Wang, Peng Yang, Xiao-Ke Tao, Sha-Sha Li, Hong-Miao Ni, Jing Pan, Hai-Feng Front Immunol Immunology OBJECTIVES: Periodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of PD with arthritis, including rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS: We performed a two-sample bidirectional Mendelian randomization (MR) analysis using publicly released genome-wide association studies (GWAS) statistics. The inverse-variance weighted (IVW) method was used as the primary analysis. We applied four complementary methods, including weighted median, weighted mode, MR-Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) to detect and correct for the effect of horizontal pleiotropy. RESULTS: Genetically determined PD did not have a causal effect on OA (OR = 1.06, 95% CI: 0.99-1.15, P = 0.09) and RA (OR = 0.99, 95% CI: 0.87-1.13, P = 0.89). Furthermore, we did not find a significant causal effect of arthritis on PD in the reverse MR analysis. The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. Horizontal pleiotropy was unlikely to distort the causal estimates according to the sensitivity analysis. CONCLUSIONS: Our MR analysis reveals non-causal association of PD with arthritis, despite observational studies reporting an association between PD and arthritis. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8825874/ /pubmed/35154127 http://dx.doi.org/10.3389/fimmu.2022.808832 Text en Copyright © 2022 Yin, Huang, Wang, Yang, Tao, Li, Ni and Pan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yin, Kang-Jia Huang, Ji-Xiang Wang, Peng Yang, Xiao-Ke Tao, Sha-Sha Li, Hong-Miao Ni, Jing Pan, Hai-Feng No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title_full | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title_fullStr | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title_full_unstemmed | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title_short | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
title_sort | no genetic causal association between periodontitis and arthritis: a bidirectional two-sample mendelian randomization analysis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825874/ https://www.ncbi.nlm.nih.gov/pubmed/35154127 http://dx.doi.org/10.3389/fimmu.2022.808832 |
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