Structural mass spectrometry decodes domain interaction and dynamics of the full-length Human Histone Deacetylase 2

Human Histone Deacetylase 2 (HDAC2) belongs to a conserved enzyme superfamily that regulates deacetylation inside cells. HDAC2 is a drug target as it is known to be upregulated in cancers and neurodegenerative disorders. It consists of globular deacetylase and C-terminus intrinsically-disordered dom...

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Detalles Bibliográficos
Autores principales: Soloviev, Zoja, Bullock, Joshua M.A., James, Juliette M.B., Sauerwein, Andrea C., Nettleship, Joanne E., Owens, Raymond J., Hansen, D. Flemming, Topf, Maya, Thalassinos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825994/
https://www.ncbi.nlm.nih.gov/pubmed/35051665
http://dx.doi.org/10.1016/j.bbapap.2022.140759

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