SARS-CoV-2 Spike-Specific CD4+ T Cell Response Is Conserved Against Variants of Concern, Including Omicron

Although accumulating data have investigated the effect of SARS-CoV-2 mutations on antibody neutralizing activity, less is known about T cell immunity. In this work, we found that the ancestral (Wuhan strain) Spike protein can efficaciously reactivate CD4+ T cell memory in subjects with previous Alp...

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Detalles Bibliográficos
Autores principales: Mazzoni, Alessio, Vanni, Anna, Spinicci, Michele, Capone, Manuela, Lamacchia, Giulia, Salvati, Lorenzo, Coppi, Marco, Antonelli, Alberto, Carnasciali, Alberto, Farahvachi, Parham, Giovacchini, Nicla, Aiezza, Noemi, Malentacchi, Francesca, Zammarchi, Lorenzo, Liotta, Francesco, Rossolini, Gian Maria, Bartoloni, Alessandro, Cosmi, Lorenzo, Maggi, Laura, Annunziato, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826050/
https://www.ncbi.nlm.nih.gov/pubmed/35154116
http://dx.doi.org/10.3389/fimmu.2022.801431

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