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The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycola...

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Detalles Bibliográficos
Autores principales:	Hall, Belinda S., Hsieh, Louise Tzung-Harn, Sacre, Sandra, Simmonds, Rachel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826060/ https://www.ncbi.nlm.nih.gov/pubmed/35154073 http://dx.doi.org/10.3389/fimmu.2021.788146

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