Aloe vera at the frontier of glycobiology and integrative medicine: Health implications of an ancient plant

Aloe vera plant extracts are ubiquitous in foods, cosmetics, and medicine. Like all plants, these extracts contain an array of potential bioactives or glycans, which may contribute to health when applied or consumed. In the Aloe vera plant, these bioactives are dominated by acemannan, a type of carbohydrate, and related complexes of saccharides, proteins, and lipids. Clinical data suggest aloe extracts may be beneficial in the management of cutaneous and some systemic conditions, such as some forms of immune dysfunction, atherogenesis, malignancy, and numerous cell functions. These extracts also contain an entourage of bioactive substances that may be allergenic and potentially toxic as well as salutary. These substances include aloin and a variety of anthracenes. The concentrations of potential allergens, aloin, and related compounds are markedly reduced through controlled decolorization processes that are utilized by leading Aloe products manufacturers. The entourage effects of contemporary Aloe vera when consumed or applied topically represent opportunities for clinical investigation which may be applied to commercial consumer products and therapeutic indications. Future research should fully explore the range of bioactive glycan components and their respective safety and efficacy. The history and ongoing popularity of Aloe vera products represent a pragmatic mandate for well-designed investigation into the diverse functional roles of glycans.