Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma

We report a case of fever of unknown origin in a patient with MDS associated with IgM‐MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LPL/WM finally revealed the latent LPL/WM in this case.

Detalles Bibliográficos
Autores principales: Motomura, Yotaro, Umezawa, Yoshihiro, Arimatsu, Tomoyuki, Okada, Keigo, Miura, Osamu, Kumagai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826126/
https://www.ncbi.nlm.nih.gov/pubmed/35154721
http://dx.doi.org/10.1002/ccr3.5372
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author Motomura, Yotaro
Umezawa, Yoshihiro
Arimatsu, Tomoyuki
Okada, Keigo
Miura, Osamu
Kumagai, Takashi
author_facet Motomura, Yotaro
Umezawa, Yoshihiro
Arimatsu, Tomoyuki
Okada, Keigo
Miura, Osamu
Kumagai, Takashi
author_sort Motomura, Yotaro
collection PubMed
description We report a case of fever of unknown origin in a patient with MDS associated with IgM‐MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LPL/WM finally revealed the latent LPL/WM in this case.
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spelling pubmed-88261262022-02-11 Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma Motomura, Yotaro Umezawa, Yoshihiro Arimatsu, Tomoyuki Okada, Keigo Miura, Osamu Kumagai, Takashi Clin Case Rep Case Reports We report a case of fever of unknown origin in a patient with MDS associated with IgM‐MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LPL/WM finally revealed the latent LPL/WM in this case. John Wiley and Sons Inc. 2022-02-09 /pmc/articles/PMC8826126/ /pubmed/35154721 http://dx.doi.org/10.1002/ccr3.5372 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Motomura, Yotaro
Umezawa, Yoshihiro
Arimatsu, Tomoyuki
Okada, Keigo
Miura, Osamu
Kumagai, Takashi
Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title_full Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title_fullStr Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title_full_unstemmed Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title_short Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
title_sort successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826126/
https://www.ncbi.nlm.nih.gov/pubmed/35154721
http://dx.doi.org/10.1002/ccr3.5372
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