Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy

Describe a novel use for a kinase inhibitor, imatinib, in young children with a known activated somatic mutation in PDGFR‐beta. Two patients with infantile myofibromatosis treated with imatinib. Case description of evaluation, diagnosis and treatment decisions for infantile myfibromatosis of the hea...

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Autores principales: Pattisapu, Prasanth, Wenger, Tara L., Dahl, John P., Bly, Randall A., Bonilla‐Velez, Juliana, Wu, Natalie, Hall, Anurekha, Rudzinski, Erin R., Perkins, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826127/
https://www.ncbi.nlm.nih.gov/pubmed/35154723
http://dx.doi.org/10.1002/ccr3.5382
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author Pattisapu, Prasanth
Wenger, Tara L.
Dahl, John P.
Bly, Randall A.
Bonilla‐Velez, Juliana
Wu, Natalie
Hall, Anurekha
Rudzinski, Erin R.
Perkins, Jonathan A.
author_facet Pattisapu, Prasanth
Wenger, Tara L.
Dahl, John P.
Bly, Randall A.
Bonilla‐Velez, Juliana
Wu, Natalie
Hall, Anurekha
Rudzinski, Erin R.
Perkins, Jonathan A.
author_sort Pattisapu, Prasanth
collection PubMed
description Describe a novel use for a kinase inhibitor, imatinib, in young children with a known activated somatic mutation in PDGFR‐beta. Two patients with infantile myofibromatosis treated with imatinib. Case description of evaluation, diagnosis and treatment decisions for infantile myfibromatosis of the head and neck. Description of medical therapy for infantile myofibromatosis in these patients. For function threatening myofibromas of a known genotype, in infants, targeted medical therapy is a treatment option.
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spelling pubmed-88261272022-02-11 Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy Pattisapu, Prasanth Wenger, Tara L. Dahl, John P. Bly, Randall A. Bonilla‐Velez, Juliana Wu, Natalie Hall, Anurekha Rudzinski, Erin R. Perkins, Jonathan A. Clin Case Rep Case Reports Describe a novel use for a kinase inhibitor, imatinib, in young children with a known activated somatic mutation in PDGFR‐beta. Two patients with infantile myofibromatosis treated with imatinib. Case description of evaluation, diagnosis and treatment decisions for infantile myfibromatosis of the head and neck. Description of medical therapy for infantile myofibromatosis in these patients. For function threatening myofibromas of a known genotype, in infants, targeted medical therapy is a treatment option. John Wiley and Sons Inc. 2022-02-09 /pmc/articles/PMC8826127/ /pubmed/35154723 http://dx.doi.org/10.1002/ccr3.5382 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Pattisapu, Prasanth
Wenger, Tara L.
Dahl, John P.
Bly, Randall A.
Bonilla‐Velez, Juliana
Wu, Natalie
Hall, Anurekha
Rudzinski, Erin R.
Perkins, Jonathan A.
Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title_full Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title_fullStr Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title_full_unstemmed Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title_short Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
title_sort avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826127/
https://www.ncbi.nlm.nih.gov/pubmed/35154723
http://dx.doi.org/10.1002/ccr3.5382
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