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Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome
BACKGROUND: A proposal has recently been advanced to change the traditional definition of nonalcoholic fatty liver disease to metabolic-associated fatty liver disease (MAFLD), to reflect the cluster of metabolic abnormalities that may be more closely associated with cardiovascular risk. Long coronav...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826155/ https://www.ncbi.nlm.nih.gov/pubmed/35146047 http://dx.doi.org/10.1093/ofid/ofac003 |
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author | Milic, Jovana Barbieri, Sara Gozzi, Licia Brigo, Alberto Beghé, Bianca Verduri, Alessia Bacca, Erica Iadisernia, Vittorio Cuomo, Gianluca Dolci, Giovanni Yaacoub, Dina Aprile, Emanuele Belli, Michela Venuta, Maria Meschiari, Marianna Sebastiani, Giada Clini, Enrico Mussini, Cristina Lonardo, Amedeo Guaraldi, Giovanni Raggi, Paolo |
author_facet | Milic, Jovana Barbieri, Sara Gozzi, Licia Brigo, Alberto Beghé, Bianca Verduri, Alessia Bacca, Erica Iadisernia, Vittorio Cuomo, Gianluca Dolci, Giovanni Yaacoub, Dina Aprile, Emanuele Belli, Michela Venuta, Maria Meschiari, Marianna Sebastiani, Giada Clini, Enrico Mussini, Cristina Lonardo, Amedeo Guaraldi, Giovanni Raggi, Paolo |
author_sort | Milic, Jovana |
collection | PubMed |
description | BACKGROUND: A proposal has recently been advanced to change the traditional definition of nonalcoholic fatty liver disease to metabolic-associated fatty liver disease (MAFLD), to reflect the cluster of metabolic abnormalities that may be more closely associated with cardiovascular risk. Long coronavirus disease 2019 (COVID-19) is a smoldering inflammatory condition, characterized by several symptom clusters. This study aims to determine the prevalence of MAFLD in patients with postacute COVID syndrome (PACS) and its association with other PACS-cluster phenotypes. METHODS: We included 235 patients observed at a single university outpatient clinic. The diagnosis of PACS was based on ≥1 cluster of symptoms: respiratory, neurocognitive, musculoskeletal, psychological, sensory, and dermatological. The outcome was prevalence of MAFLD detected by transient elastography during the first postdischarge follow-up outpatient visit. The prevalence of MAFLD at the time of hospital admission was calculated retrospectively using the hepatic steatosis index. RESULTS: Of 235 patients, 162 (69%) were men (median age 61). The prevalence of MAFLD was 55.3% at follow-up and 37.3% on admission (P < .001). Insulin resistance (odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.14–1.96), body mass index (OR = 1.14; 95% CI, 1.04–1.24), and the metabolic syndrome (OR = 2.54; 95% CI, 1.13–5.68) were independent predictors of MAFLD. The number of PACS clusters was inversely associated with MAFLD (OR = 0.86; 95% CI, .76–0.97). Thirty-one patients (13.2%) had MAFLD with no other associated PACS clusters. All correlations between MAFLD and other PACS clusters were weak. CONCLUSIONS: Metabolic-associated fatty liver disease was highly prevalent after hospital discharge and may represent a specific PACS-cluster phenotype, with potential long-term metabolic and cardiovascular health implications. |
format | Online Article Text |
id | pubmed-8826155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88261552022-02-09 Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome Milic, Jovana Barbieri, Sara Gozzi, Licia Brigo, Alberto Beghé, Bianca Verduri, Alessia Bacca, Erica Iadisernia, Vittorio Cuomo, Gianluca Dolci, Giovanni Yaacoub, Dina Aprile, Emanuele Belli, Michela Venuta, Maria Meschiari, Marianna Sebastiani, Giada Clini, Enrico Mussini, Cristina Lonardo, Amedeo Guaraldi, Giovanni Raggi, Paolo Open Forum Infect Dis Major Article BACKGROUND: A proposal has recently been advanced to change the traditional definition of nonalcoholic fatty liver disease to metabolic-associated fatty liver disease (MAFLD), to reflect the cluster of metabolic abnormalities that may be more closely associated with cardiovascular risk. Long coronavirus disease 2019 (COVID-19) is a smoldering inflammatory condition, characterized by several symptom clusters. This study aims to determine the prevalence of MAFLD in patients with postacute COVID syndrome (PACS) and its association with other PACS-cluster phenotypes. METHODS: We included 235 patients observed at a single university outpatient clinic. The diagnosis of PACS was based on ≥1 cluster of symptoms: respiratory, neurocognitive, musculoskeletal, psychological, sensory, and dermatological. The outcome was prevalence of MAFLD detected by transient elastography during the first postdischarge follow-up outpatient visit. The prevalence of MAFLD at the time of hospital admission was calculated retrospectively using the hepatic steatosis index. RESULTS: Of 235 patients, 162 (69%) were men (median age 61). The prevalence of MAFLD was 55.3% at follow-up and 37.3% on admission (P < .001). Insulin resistance (odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.14–1.96), body mass index (OR = 1.14; 95% CI, 1.04–1.24), and the metabolic syndrome (OR = 2.54; 95% CI, 1.13–5.68) were independent predictors of MAFLD. The number of PACS clusters was inversely associated with MAFLD (OR = 0.86; 95% CI, .76–0.97). Thirty-one patients (13.2%) had MAFLD with no other associated PACS clusters. All correlations between MAFLD and other PACS clusters were weak. CONCLUSIONS: Metabolic-associated fatty liver disease was highly prevalent after hospital discharge and may represent a specific PACS-cluster phenotype, with potential long-term metabolic and cardiovascular health implications. Oxford University Press 2022-01-10 /pmc/articles/PMC8826155/ /pubmed/35146047 http://dx.doi.org/10.1093/ofid/ofac003 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Article Milic, Jovana Barbieri, Sara Gozzi, Licia Brigo, Alberto Beghé, Bianca Verduri, Alessia Bacca, Erica Iadisernia, Vittorio Cuomo, Gianluca Dolci, Giovanni Yaacoub, Dina Aprile, Emanuele Belli, Michela Venuta, Maria Meschiari, Marianna Sebastiani, Giada Clini, Enrico Mussini, Cristina Lonardo, Amedeo Guaraldi, Giovanni Raggi, Paolo Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title | Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title_full | Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title_fullStr | Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title_full_unstemmed | Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title_short | Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome |
title_sort | metabolic-associated fatty liver disease is highly prevalent in the postacute covid syndrome |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826155/ https://www.ncbi.nlm.nih.gov/pubmed/35146047 http://dx.doi.org/10.1093/ofid/ofac003 |
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