Cargando…
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation
Mechanical damage is one of the predisposing factors of inflammation, and it runs through the entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic inflammatory diseases. The mechanism of how mechanical forces induce inflammation is not full...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826255/ https://www.ncbi.nlm.nih.gov/pubmed/35154133 http://dx.doi.org/10.3389/fimmu.2022.816149 |
_version_ | 1784647394325954560 |
---|---|
author | Liu, Hailin Hu, Jialing Zheng, Qingcui Feng, Xiaojin Zhan, Fenfang Wang, Xifeng Xu, Guohai Hua, Fuzhou |
author_facet | Liu, Hailin Hu, Jialing Zheng, Qingcui Feng, Xiaojin Zhan, Fenfang Wang, Xifeng Xu, Guohai Hua, Fuzhou |
author_sort | Liu, Hailin |
collection | PubMed |
description | Mechanical damage is one of the predisposing factors of inflammation, and it runs through the entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic inflammatory diseases. The mechanism of how mechanical forces induce inflammation is not fully understood. Piezo1 is a newly discovered mechanically sensitive ion channel. The Piezo1 channel opens in response to mechanical stimuli, transducing mechanical signals into an inflammatory cascade in the cell leading to tissue inflammation. A large amount of evidence shows that Piezo1 plays a vital role in the occurrence and progression of chronic inflammatory diseases. This mini-review briefly presents new evidence that Piezo1 responds to different mechanical stresses to trigger inflammation in various tissues. The discovery of Piezo1 provides new insights for the treatment of chronic inflammatory diseases related to mechanical stress. Inhibiting the transduction of damaging mechanical signals into inflammatory signals can inhibit inflammation and improve the outcome of inflammation at an early stage. The pharmacology of Piezo1 has shown bright prospects. The development of tissue-specific Piezo1 drugs for clinical use may be a new target for treating chronic inflammation. |
format | Online Article Text |
id | pubmed-8826255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88262552022-02-10 Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation Liu, Hailin Hu, Jialing Zheng, Qingcui Feng, Xiaojin Zhan, Fenfang Wang, Xifeng Xu, Guohai Hua, Fuzhou Front Immunol Immunology Mechanical damage is one of the predisposing factors of inflammation, and it runs through the entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic inflammatory diseases. The mechanism of how mechanical forces induce inflammation is not fully understood. Piezo1 is a newly discovered mechanically sensitive ion channel. The Piezo1 channel opens in response to mechanical stimuli, transducing mechanical signals into an inflammatory cascade in the cell leading to tissue inflammation. A large amount of evidence shows that Piezo1 plays a vital role in the occurrence and progression of chronic inflammatory diseases. This mini-review briefly presents new evidence that Piezo1 responds to different mechanical stresses to trigger inflammation in various tissues. The discovery of Piezo1 provides new insights for the treatment of chronic inflammatory diseases related to mechanical stress. Inhibiting the transduction of damaging mechanical signals into inflammatory signals can inhibit inflammation and improve the outcome of inflammation at an early stage. The pharmacology of Piezo1 has shown bright prospects. The development of tissue-specific Piezo1 drugs for clinical use may be a new target for treating chronic inflammation. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8826255/ /pubmed/35154133 http://dx.doi.org/10.3389/fimmu.2022.816149 Text en Copyright © 2022 Liu, Hu, Zheng, Feng, Zhan, Wang, Xu and Hua https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Liu, Hailin Hu, Jialing Zheng, Qingcui Feng, Xiaojin Zhan, Fenfang Wang, Xifeng Xu, Guohai Hua, Fuzhou Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title | Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title_full | Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title_fullStr | Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title_full_unstemmed | Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title_short | Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation |
title_sort | piezo1 channels as force sensors in mechanical force-related chronic inflammation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826255/ https://www.ncbi.nlm.nih.gov/pubmed/35154133 http://dx.doi.org/10.3389/fimmu.2022.816149 |
work_keys_str_mv | AT liuhailin piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT hujialing piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT zhengqingcui piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT fengxiaojin piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT zhanfenfang piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT wangxifeng piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT xuguohai piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation AT huafuzhou piezo1channelsasforcesensorsinmechanicalforcerelatedchronicinflammation |