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Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population

BACKGROUND: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. METHODS: Between January 2...

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Autores principales: Mu, Min, Jing, Li, Zou, Yuan-Jie, Tao, Xing-Rong, Wang, Fei, Lu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826332/
https://www.ncbi.nlm.nih.gov/pubmed/35223600
http://dx.doi.org/10.18502/ijph.v50i11.7580
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author Mu, Min
Jing, Li
Zou, Yuan-Jie
Tao, Xing-Rong
Wang, Fei
Lu, Jun
author_facet Mu, Min
Jing, Li
Zou, Yuan-Jie
Tao, Xing-Rong
Wang, Fei
Lu, Jun
author_sort Mu, Min
collection PubMed
description BACKGROUND: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. METHODS: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. RESULTS: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ(2) = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ(2) = 4.784, OR = 1.414, 95% CI: 1.036–1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ(2) = 4.192, OR = 0.507; 95% CI: 0.262–0.981, P < 0.05). CONCLUSION: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients.
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spelling pubmed-88263322022-02-25 Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population Mu, Min Jing, Li Zou, Yuan-Jie Tao, Xing-Rong Wang, Fei Lu, Jun Iran J Public Health Original Article BACKGROUND: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. METHODS: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. RESULTS: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ(2) = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ(2) = 4.784, OR = 1.414, 95% CI: 1.036–1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ(2) = 4.192, OR = 0.507; 95% CI: 0.262–0.981, P < 0.05). CONCLUSION: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients. Tehran University of Medical Sciences 2021-11 /pmc/articles/PMC8826332/ /pubmed/35223600 http://dx.doi.org/10.18502/ijph.v50i11.7580 Text en Copyright © 2021 Mu et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Mu, Min
Jing, Li
Zou, Yuan-Jie
Tao, Xing-Rong
Wang, Fei
Lu, Jun
Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_full Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_fullStr Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_full_unstemmed Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_short Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_sort polymorphisms of fatty acid elongase 2 gene afftects risk of pulmonary tuberculosis in china han population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826332/
https://www.ncbi.nlm.nih.gov/pubmed/35223600
http://dx.doi.org/10.18502/ijph.v50i11.7580
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