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A Mediator-cohesin axis controls heterochromatin domain formation

The genome consists of regions of transcriptionally active euchromatin and more silent heterochromatin. We reveal that the formation of heterochromatin domains requires cohesin turnover on DNA. Stabilization of cohesin on DNA through depletion of its release factor WAPL leads to a near-complete loss...

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Detalles Bibliográficos
Autores principales:	Haarhuis, Judith H. I., van der Weide, Robin H., Blomen, Vincent A., Flach, Koen D., Teunissen, Hans, Willems, Laureen, Brummelkamp, Thijn R., Rowland, Benjamin D., de Wit, Elzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826356/ https://www.ncbi.nlm.nih.gov/pubmed/35136067 http://dx.doi.org/10.1038/s41467-022-28377-7

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