Cargando…

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway

Although there are many studies on the relationship between genetic polymorphisms and the incidence of diseases, mechanisms are rarely known. We report the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promotes the occurrence and progression of hepatocellula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Caie, Gao, Na, Yang, Lukui, Guo, Yuanyuan, Fang, Yan, Wang, Tong, Xu, Chen, Li, Gui fang, Zhou, Jun, Zhang, Yunfei, Wen, Qiang, Qiao, Hailing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826371/ https://www.ncbi.nlm.nih.gov/pubmed/35136014 http://dx.doi.org/10.1038/s41419-022-04584-4

Ejemplares similares

Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved
por: Tarakji, Iman, et al.
Publicado: (2018)

Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the STAT4 SLE risk allele rs7574865[T]
por: Hagberg, Niklas, et al.
Publicado: (2019)

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression
por: Lamana, Amalia, et al.
Publicado: (2015)

The Association Between STAT4 rs7574865 Polymorphism and the Susceptibility of Autoimmune Thyroid Disease: A Meta-Analysis
por: Gao, Xueren, et al.
Publicado: (2019)

Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus
por: Esparza Guerrero, Yussef, et al.
Publicado: (2023)

The TT Genotype of the STAT4 rs7574865 Polymorphism Is Associated with High Disease Activity and Disability in Patients with Early Arthritis
por: Lamana, Amalia, et al.
Publicado: (2012)

Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups
por: Hiz, Meliha M., et al.
Publicado: (2016)

Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients
por: Abdelmajed, Samar Samir, et al.
Publicado: (2021)

Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset
por: Glas, Jürgen, et al.
Publicado: (2010)

Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls
por: Xu, Ling, et al.
Publicado: (2014)

STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C Polymorphisms Influence the Risk of Developing Juvenile Idiopathic Arthritis in Han Chinese Patients
por: Fan, Zhi-Dan, et al.
Publicado: (2015)

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
por: Hagberg, Niklas, et al.
Publicado: (2018)

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris
por: Juczynska, K., et al.
Publicado: (2020)

Xue-Jie-San restricts ferroptosis in Crohn’s disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop
por: Gao, Ying, et al.
Publicado: (2023)

Fgl2: link between hepatitis B and SARS?
por: Robertson, Morag
Publicado: (2003)

Targeting FGL2 in glioma immunosuppression and malignant progression
por: Ma, Xiaoyu, et al.
Publicado: (2022)

sFgl2 gene-modified MSCs regulate the differentiation of CD4(+) T cells in the treatment of autoimmune hepatitis
por: Ji, Wenbin, et al.
Publicado: (2023)

The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway
por: Li, Xueying, et al.
Publicado: (2022)

Polymorphisms of the STAT4 gene in the pathogenesis of tuberculosis
por: Wu, Shouquan, et al.
Publicado: (2018)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

sFgl2-Treg Positive Feedback Pathway Protects against Atherosclerosis
por: An, Tianhui, et al.
Publicado: (2023)

The Role of FGL2 in the Pathogenesis and Treatment of Hepatitis C Virus Infection
por: Shalev, Itay, et al.
Publicado: (2010)

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma
por: Yuan, Kai, et al.
Publicado: (2020)

Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma
por: Glebauskiene, Brigita, et al.
Publicado: (2017)

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region
por: Kawasaki, Aya, et al.
Publicado: (2008)

Transcription factor KLF4 regulated STAT1 to promote M1 polarization of macrophages in rheumatoid arthritis
por: Ye, Qiao, et al.
Publicado: (2022)

Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics
por: Kassogue, Yaya, et al.
Publicado: (2021)

NDRG4 Alleviates Myocardial Infarction-Induced Apoptosis through the JAK2/STAT3 Pathway
por: Zhao, Changliang, et al.
Publicado: (2022)

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
por: Hua, Yaping, et al.
Publicado: (2022)

Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer
por: Shi, An-Ping, et al.
Publicado: (2022)

Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer
por: Feng, Yanyan, et al.
Publicado: (2020)

T lymphocytes of patients with SLE lack Stat4
por: Aringer, M, et al.
Publicado: (2001)

STAT5 and CD4 (+) T Cell Immunity
por: Owen, David L., et al.
Publicado: (2017)

T-Bet Is Dependent on Stat-4 Inhibiting Acute Colitis but Not Stat-1 Using L4 Somatic Antigen of Heligmosomoides polygyrus
por: Endharti, Agustina Tri, et al.
Publicado: (2018)

Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation
por: Liu, Xin-guang, et al.
Publicado: (2016)

Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke
por: Iluţ, Silvina, et al.
Publicado: (2023)

As(4)S(4) Exhibits Good Killing Effect on Multiple Myeloma Cells Via Repressing SOCS1 Methylation-Mediated JAK2/STAT3 Signaling Pathway
por: Wu, Di, et al.
Publicado: (2019)

STAT2: A shape-shifting anti-viral super STAT
por: Chowdhury, Fatema Z., et al.
Publicado: (2013)

FGL2 promotes tumor progression in the CNS by suppressing CD103(+) dendritic cell differentiation
por: Yan, Jun, et al.
Publicado: (2019)

Lnc-PXMP4-2-4 alleviates myocardial cell damage by activating the JAK2/STAT3 signaling pathway
por: Zhang, Hong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5spq1d10f11ec77d9qimil7bmv