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Isoform-level quantification for single-cell RNA sequencing

MOTIVATION: RNA expression at isoform level is biologically more informative than at gene level and can potentially reveal cellular subsets and corresponding biomarkers that are not visible at gene level. However, due to the strong 3ʹ bias sequencing protocol, mRNA quantification for high-throughput...

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Detalles Bibliográficos
Autores principales: Pan, Lu, Dinh, Huy Q, Pawitan, Yudi, Vu, Trung Nghia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826380/
https://www.ncbi.nlm.nih.gov/pubmed/34864849
http://dx.doi.org/10.1093/bioinformatics/btab807