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Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders. Although the primary function of neuroinflammation is to protect the nervous system from an insult, the complex and sequential response of activated glial c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826404/ https://www.ncbi.nlm.nih.gov/pubmed/35154065 http://dx.doi.org/10.3389/fimmu.2021.714248 |
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author | Del’Arco, Ana Elisa Argolo, Deivison Silva Guillemin, Gilles Costa, Maria de Fátima Dias Costa, Silvia Lima Pinheiro, Alexandre Moraes |
author_facet | Del’Arco, Ana Elisa Argolo, Deivison Silva Guillemin, Gilles Costa, Maria de Fátima Dias Costa, Silvia Lima Pinheiro, Alexandre Moraes |
author_sort | Del’Arco, Ana Elisa |
collection | PubMed |
description | Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders. Although the primary function of neuroinflammation is to protect the nervous system from an insult, the complex and sequential response of activated glial cells can lead to neurological damage. Depending on the type of insults and the time post-insult, the inflammatory response can be neuroprotective, neurotoxic, or, depending on the glial cell types, both. There are multiple pathways activated and many bioactive intermediates are released during neuroinflammation. One of the most common one is the kynurenine pathway, catabolizing tryptophan, which is involved in immune regulation, neuroprotection, and neurotoxicity. Different models have been used to study the kynurenine pathway metabolites to understand their involvements in the development and maintenance of the inflammatory processes triggered by infections. Among them, the parasitic infection Neospora caninum could be used as a relevant model to study the role of the kynurenine pathway in the neuroinflammatory response and the subset of cells involved. |
format | Online Article Text |
id | pubmed-8826404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88264042022-02-10 Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum Del’Arco, Ana Elisa Argolo, Deivison Silva Guillemin, Gilles Costa, Maria de Fátima Dias Costa, Silvia Lima Pinheiro, Alexandre Moraes Front Immunol Immunology Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders. Although the primary function of neuroinflammation is to protect the nervous system from an insult, the complex and sequential response of activated glial cells can lead to neurological damage. Depending on the type of insults and the time post-insult, the inflammatory response can be neuroprotective, neurotoxic, or, depending on the glial cell types, both. There are multiple pathways activated and many bioactive intermediates are released during neuroinflammation. One of the most common one is the kynurenine pathway, catabolizing tryptophan, which is involved in immune regulation, neuroprotection, and neurotoxicity. Different models have been used to study the kynurenine pathway metabolites to understand their involvements in the development and maintenance of the inflammatory processes triggered by infections. Among them, the parasitic infection Neospora caninum could be used as a relevant model to study the role of the kynurenine pathway in the neuroinflammatory response and the subset of cells involved. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8826404/ /pubmed/35154065 http://dx.doi.org/10.3389/fimmu.2021.714248 Text en Copyright © 2022 Del’Arco, Argolo, Guillemin, Costa, Costa and Pinheiro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Del’Arco, Ana Elisa Argolo, Deivison Silva Guillemin, Gilles Costa, Maria de Fátima Dias Costa, Silvia Lima Pinheiro, Alexandre Moraes Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum |
title | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
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title_full | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
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title_fullStr | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
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title_full_unstemmed | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
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title_short | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
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title_sort | neurological infection, kynurenine pathway, and parasitic infection by neospora caninum |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826404/ https://www.ncbi.nlm.nih.gov/pubmed/35154065 http://dx.doi.org/10.3389/fimmu.2021.714248 |
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