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Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors (GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The mechanisms of lysophospholipid recognition by an active GPCR, and the activations of lysophosph...

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Detalles Bibliográficos
Autores principales: Liu, Shian, Paknejad, Navid, Zhu, Lan, Kihara, Yasuyuki, Ray, Manisha, Chun, Jerold, Liu, Wei, Hite, Richard K., Huang, Xin-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826421/
https://www.ncbi.nlm.nih.gov/pubmed/35136060
http://dx.doi.org/10.1038/s41467-022-28417-2