Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Altered patterns of 5hmC and 5mC are widely reported in human cancers and loss of 5hmC correlates with p...

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Detalles Bibliográficos
Autores principales: Lopez-Bertoni, Hernando, Johnson, Amanda, Rui, Yuan, Lal, Bachchu, Sall, Sophie, Malloy, Maureen, Coulter, Jonathan B., Lugo-Fagundo, Maria, Shudir, Sweta, Khela, Harmon, Caputo, Christopher, Green, Jordan J., Laterra, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826438/
https://www.ncbi.nlm.nih.gov/pubmed/35136034
http://dx.doi.org/10.1038/s41392-021-00857-0

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