CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling

Epithelial polarity is controlled by a polarity machinery that includes Rho GTPase CDC42 and Scribble/PAR. By using intestinal stem cell (ISC)-specific deletion of CDC42 in olfactomedin-4 (Olfm4)-internal ribosome entry site (IRES)-EGFP/CreERT2;CDC42(flox/flox) mice, we find that CDC42 loss initiate...

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Detalles Bibliográficos
Autores principales: Zhang, Zheng, Zhang, Feng, Davis, Ashley Kuenzi, Xin, Mei, Walz, Gerd, Tian, Weidong, Zheng, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826493/
https://www.ncbi.nlm.nih.gov/pubmed/35021092
http://dx.doi.org/10.1016/j.celrep.2021.110009

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