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Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia

Tropical indigenous peoples in Asia (TIA) attract much attention for their unique appearance, whereas their genetic history and adaptive evolution remain mysteries. We conducted a comprehensive study to characterize the genetic distinction and connection of broad geographical TIAs. Despite the diver...

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Autores principales: Deng, Lian, Pan, Yuwen, Wang, Yinan, Chen, Hao, Yuan, Kai, Chen, Sihan, Lu, Dongsheng, Lu, Yan, Mokhtar, Siti Shuhada, Rahman, Thuhairah Abdul, Hoh, Boon-Peng, Xu, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826522/
https://www.ncbi.nlm.nih.gov/pubmed/34940850
http://dx.doi.org/10.1093/molbev/msab361
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author Deng, Lian
Pan, Yuwen
Wang, Yinan
Chen, Hao
Yuan, Kai
Chen, Sihan
Lu, Dongsheng
Lu, Yan
Mokhtar, Siti Shuhada
Rahman, Thuhairah Abdul
Hoh, Boon-Peng
Xu, Shuhua
author_facet Deng, Lian
Pan, Yuwen
Wang, Yinan
Chen, Hao
Yuan, Kai
Chen, Sihan
Lu, Dongsheng
Lu, Yan
Mokhtar, Siti Shuhada
Rahman, Thuhairah Abdul
Hoh, Boon-Peng
Xu, Shuhua
author_sort Deng, Lian
collection PubMed
description Tropical indigenous peoples in Asia (TIA) attract much attention for their unique appearance, whereas their genetic history and adaptive evolution remain mysteries. We conducted a comprehensive study to characterize the genetic distinction and connection of broad geographical TIAs. Despite the diverse genetic makeup and large interarea genetic differentiation between the TIA groups, we identified a basal Asian ancestry (bASN) specifically shared by these populations. The bASN ancestry was relatively enriched in ancient Asian human genomes dated as early as ∼50,000 years before the present and diminished in more recent history. Notably, the bASN ancestry is unlikely to be derived from archaic hominins. Instead, we suggest it may be better modeled as a survived lineage of the initial peopling of Asia. Shared adaptations inherited from the ancient Asian ancestry were detected among the TIA groups (e.g., LIMS1 for hair morphology, and COL24A1 for bone formation), and they are enriched in neurological functions either at an identical locus (e.g., NKAIN3), or different loci in an identical gene (e.g., TENM4). The bASN ancestry could also have formed the substrate of the genetic architecture of the dark pigmentation observed in the TIA peoples. We hypothesize that phenotypic convergence of the dark pigmentation in TIAs could have resulted from parallel (e.g., DDB1/DAK) or genetic convergence driven by admixture (e.g., MTHFD1 and RAD18), new mutations (e.g., STK11), or notably purifying selection (e.g., MC1R). Our results provide new insights into the initial peopling of Asia and an advanced understanding of the phenotypic convergence of the TIA peoples.
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spelling pubmed-88265222022-02-09 Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia Deng, Lian Pan, Yuwen Wang, Yinan Chen, Hao Yuan, Kai Chen, Sihan Lu, Dongsheng Lu, Yan Mokhtar, Siti Shuhada Rahman, Thuhairah Abdul Hoh, Boon-Peng Xu, Shuhua Mol Biol Evol Discoveries Tropical indigenous peoples in Asia (TIA) attract much attention for their unique appearance, whereas their genetic history and adaptive evolution remain mysteries. We conducted a comprehensive study to characterize the genetic distinction and connection of broad geographical TIAs. Despite the diverse genetic makeup and large interarea genetic differentiation between the TIA groups, we identified a basal Asian ancestry (bASN) specifically shared by these populations. The bASN ancestry was relatively enriched in ancient Asian human genomes dated as early as ∼50,000 years before the present and diminished in more recent history. Notably, the bASN ancestry is unlikely to be derived from archaic hominins. Instead, we suggest it may be better modeled as a survived lineage of the initial peopling of Asia. Shared adaptations inherited from the ancient Asian ancestry were detected among the TIA groups (e.g., LIMS1 for hair morphology, and COL24A1 for bone formation), and they are enriched in neurological functions either at an identical locus (e.g., NKAIN3), or different loci in an identical gene (e.g., TENM4). The bASN ancestry could also have formed the substrate of the genetic architecture of the dark pigmentation observed in the TIA peoples. We hypothesize that phenotypic convergence of the dark pigmentation in TIAs could have resulted from parallel (e.g., DDB1/DAK) or genetic convergence driven by admixture (e.g., MTHFD1 and RAD18), new mutations (e.g., STK11), or notably purifying selection (e.g., MC1R). Our results provide new insights into the initial peopling of Asia and an advanced understanding of the phenotypic convergence of the TIA peoples. Oxford University Press 2021-12-23 /pmc/articles/PMC8826522/ /pubmed/34940850 http://dx.doi.org/10.1093/molbev/msab361 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discoveries
Deng, Lian
Pan, Yuwen
Wang, Yinan
Chen, Hao
Yuan, Kai
Chen, Sihan
Lu, Dongsheng
Lu, Yan
Mokhtar, Siti Shuhada
Rahman, Thuhairah Abdul
Hoh, Boon-Peng
Xu, Shuhua
Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title_full Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title_fullStr Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title_full_unstemmed Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title_short Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia
title_sort genetic connections and convergent evolution of tropical indigenous peoples in asia
topic Discoveries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826522/
https://www.ncbi.nlm.nih.gov/pubmed/34940850
http://dx.doi.org/10.1093/molbev/msab361
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