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The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients
INTRODUCTION: The development and progression of hepatocellular carcinoma (HCC) is a multistage process involving the deregulation of genes that are crucial to cellular processes. Multiple risk factors are correlated with HCC. MicroRNA is differentially expressed in the development of different type...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826692/ https://www.ncbi.nlm.nih.gov/pubmed/35154526 http://dx.doi.org/10.5114/aoms/100600 |
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author | Allam, Maha M. Diab, Karema A. Khalil, Fatma O. Khalaf, Fatma A. Abdel-Samiee, Mohamed Sheble, Nashwa Eljaky, Mohamed A. Zayed, Essam Othman, Warda Abd-Elkreem, Mervat Abdelsameea, Eman |
author_facet | Allam, Maha M. Diab, Karema A. Khalil, Fatma O. Khalaf, Fatma A. Abdel-Samiee, Mohamed Sheble, Nashwa Eljaky, Mohamed A. Zayed, Essam Othman, Warda Abd-Elkreem, Mervat Abdelsameea, Eman |
author_sort | Allam, Maha M. |
collection | PubMed |
description | INTRODUCTION: The development and progression of hepatocellular carcinoma (HCC) is a multistage process involving the deregulation of genes that are crucial to cellular processes. Multiple risk factors are correlated with HCC. MicroRNA is differentially expressed in the development of different types of malignancies, including hepatic malignancy. Single nucleotide polymorphisms (SNPs) are the most common sequence variation in the human genome. SNPs in miRNAs may affect transcription, processing, or target recognition and result in malignant disease. The aim of the study was to determine the association between microRNA gene polymorphisms and the development of HCC in Egyptian patients. MATERIAL AND METHODS: This study included 200 individuals who were matched in age and sex. Tumour staging was done using the BCLC staging system. Quantification and genotyping of microRNA were performed. RESULTS: Among the 200 patients, 2 groups were described: group I included 90 HCC patients with a male majority (72.2%), and group II comprised 110 controls. Three microRNA SNPs were assayed in both patients and controls. There was a significant association between rs10061133 miR-499b and the risk of HCC. The genotypes GG or G allele were significantly associated with an increased risk of HCC (GG: OR = 2.91, 95% CI: 1.23–4.22, p = 0.013; G allele: OR = 1.79, 95% CI: 1.12–2.15, p = 0.026) compared with the genotype of AA or AG or A allele. CONCLUSIONS: There is an association between the miRNA SNPs and the susceptibility to HCC, to explore some roles and mechanisms of SNPs within miRNAs in the occurrence and development of HCC. |
format | Online Article Text |
id | pubmed-8826692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-88266922022-02-11 The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients Allam, Maha M. Diab, Karema A. Khalil, Fatma O. Khalaf, Fatma A. Abdel-Samiee, Mohamed Sheble, Nashwa Eljaky, Mohamed A. Zayed, Essam Othman, Warda Abd-Elkreem, Mervat Abdelsameea, Eman Arch Med Sci Clinical Research INTRODUCTION: The development and progression of hepatocellular carcinoma (HCC) is a multistage process involving the deregulation of genes that are crucial to cellular processes. Multiple risk factors are correlated with HCC. MicroRNA is differentially expressed in the development of different types of malignancies, including hepatic malignancy. Single nucleotide polymorphisms (SNPs) are the most common sequence variation in the human genome. SNPs in miRNAs may affect transcription, processing, or target recognition and result in malignant disease. The aim of the study was to determine the association between microRNA gene polymorphisms and the development of HCC in Egyptian patients. MATERIAL AND METHODS: This study included 200 individuals who were matched in age and sex. Tumour staging was done using the BCLC staging system. Quantification and genotyping of microRNA were performed. RESULTS: Among the 200 patients, 2 groups were described: group I included 90 HCC patients with a male majority (72.2%), and group II comprised 110 controls. Three microRNA SNPs were assayed in both patients and controls. There was a significant association between rs10061133 miR-499b and the risk of HCC. The genotypes GG or G allele were significantly associated with an increased risk of HCC (GG: OR = 2.91, 95% CI: 1.23–4.22, p = 0.013; G allele: OR = 1.79, 95% CI: 1.12–2.15, p = 0.026) compared with the genotype of AA or AG or A allele. CONCLUSIONS: There is an association between the miRNA SNPs and the susceptibility to HCC, to explore some roles and mechanisms of SNPs within miRNAs in the occurrence and development of HCC. Termedia Publishing House 2021-03-18 /pmc/articles/PMC8826692/ /pubmed/35154526 http://dx.doi.org/10.5114/aoms/100600 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Allam, Maha M. Diab, Karema A. Khalil, Fatma O. Khalaf, Fatma A. Abdel-Samiee, Mohamed Sheble, Nashwa Eljaky, Mohamed A. Zayed, Essam Othman, Warda Abd-Elkreem, Mervat Abdelsameea, Eman The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title | The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title_full | The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title_fullStr | The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title_full_unstemmed | The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title_short | The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients |
title_sort | association between micro-rna gene polymorphisms and the development of hepatocellular carcinoma in egyptian patients |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826692/ https://www.ncbi.nlm.nih.gov/pubmed/35154526 http://dx.doi.org/10.5114/aoms/100600 |
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