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A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle

The COVID-19 causing coronavirus (SARS-CoV-2) remains a public health threat worldwide. SARS-CoV-2 enters human lung cells via its spike glycoprotein binding to angiotensin-converting enzyme 2 (ACE2). Notably, the cleavage of the spike by the host cell protease furin in virus-producing cells is crit...

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Detalles Bibliográficos
Autores principales:	Mondal, Tanmoy, Shivange, Gururaj, Habieb, Alaa, Tushir-Singh, Jogender
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826744/ https://www.ncbi.nlm.nih.gov/pubmed/35138160 http://dx.doi.org/10.1128/spectrum.02364-21

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