Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study

INTRODUCTION: Hypertension is the leading direct cause of death in the world and one of the most important risk factors for cardiovascular disease (CVD). Elevated blood pressure (BP) often coexists with lipid disorders and is an additional factor that increases CV risk. Nowadays, we are able to dist...

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Autores principales: Chruściel, Piotr, Stemplewska, Paulina, Stemplewski, Adam, Wattad, Mohamad, Bielecka-Dąbrowa, Agata, Maciejewski, Marek, Penson, Peter, Bartlomiejczyk, Marcin A., Banach, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826797/
https://www.ncbi.nlm.nih.gov/pubmed/35154522
http://dx.doi.org/10.5114/aoms.2019.86197
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author Chruściel, Piotr
Stemplewska, Paulina
Stemplewski, Adam
Wattad, Mohamad
Bielecka-Dąbrowa, Agata
Maciejewski, Marek
Penson, Peter
Bartlomiejczyk, Marcin A.
Banach, Maciej
author_facet Chruściel, Piotr
Stemplewska, Paulina
Stemplewski, Adam
Wattad, Mohamad
Bielecka-Dąbrowa, Agata
Maciejewski, Marek
Penson, Peter
Bartlomiejczyk, Marcin A.
Banach, Maciej
author_sort Chruściel, Piotr
collection PubMed
description INTRODUCTION: Hypertension is the leading direct cause of death in the world and one of the most important risk factors for cardiovascular disease (CVD). Elevated blood pressure (BP) often coexists with lipid disorders and is an additional factor that increases CV risk. Nowadays, we are able to distinguish low density lipoproteins (LDL) and high density lipoproteins (HDL) subfractions. Except LDL also HDL small subfractions can increase the risk of CV events. Therefore, we aimed to investigate the associations between changes of lipoprotein subfractions and the risk of hypertension development. MATERIAL AND METHODS: In 2-year long study 200 volunteers with normal blood pressure at the age of 19–32 years were included. Each volunteer underwent detailed medical examination, 12-lead electrocardiogram was taken at rest, echocardiogram, lipid subfraction assessment (using Lipoprint(®)) and two 24-hour BP measurements. RESULTS: Mean total cholesterol concentration was 189 mg/dl (4.89 mmol/l), with mean LDL concentration of 107 mg/dl (2.77 mmol/l), HDL of 63 mg/dl (1.63 mmo/l), very low-density lipoprotein (VLDL) of 40 mg/dl (1.04 mmol/l) and triglycerides (TG) of 89 mg/dl (1.00 mmol/l). Subfractions LDL 1–3 were most abundant, LDL 4–5 making up a marginal portion and LDL 6–7 were not observed. Whereas, subfractions HDL 4–6 were most abundant, in lower concentration was present HDL 1–3 and HDL 8–10. We showed that increased systolic blood pressure coreclated significantly with HDL cholesterol concentrations (p = 0.0078), HDL intermediate subgractions (p = 0.0451), with HDL-3 subfraction (p = 0.0229), and intermediate density lipoprotein-A (IDL-A) (p = 0.038). A significant correlation between increased diastolic blood pressure and HDL lipoprotein levels (p = 0.0454) was only observed. CONCLUSIONS: Obtained results indicating correlation between total HDL levels and HDL-3 subfraction concentration (for systolic BP) and the tendency to develop hypertension.
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spelling pubmed-88267972022-02-11 Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study Chruściel, Piotr Stemplewska, Paulina Stemplewski, Adam Wattad, Mohamad Bielecka-Dąbrowa, Agata Maciejewski, Marek Penson, Peter Bartlomiejczyk, Marcin A. Banach, Maciej Arch Med Sci Clinical Research INTRODUCTION: Hypertension is the leading direct cause of death in the world and one of the most important risk factors for cardiovascular disease (CVD). Elevated blood pressure (BP) often coexists with lipid disorders and is an additional factor that increases CV risk. Nowadays, we are able to distinguish low density lipoproteins (LDL) and high density lipoproteins (HDL) subfractions. Except LDL also HDL small subfractions can increase the risk of CV events. Therefore, we aimed to investigate the associations between changes of lipoprotein subfractions and the risk of hypertension development. MATERIAL AND METHODS: In 2-year long study 200 volunteers with normal blood pressure at the age of 19–32 years were included. Each volunteer underwent detailed medical examination, 12-lead electrocardiogram was taken at rest, echocardiogram, lipid subfraction assessment (using Lipoprint(®)) and two 24-hour BP measurements. RESULTS: Mean total cholesterol concentration was 189 mg/dl (4.89 mmol/l), with mean LDL concentration of 107 mg/dl (2.77 mmol/l), HDL of 63 mg/dl (1.63 mmo/l), very low-density lipoprotein (VLDL) of 40 mg/dl (1.04 mmol/l) and triglycerides (TG) of 89 mg/dl (1.00 mmol/l). Subfractions LDL 1–3 were most abundant, LDL 4–5 making up a marginal portion and LDL 6–7 were not observed. Whereas, subfractions HDL 4–6 were most abundant, in lower concentration was present HDL 1–3 and HDL 8–10. We showed that increased systolic blood pressure coreclated significantly with HDL cholesterol concentrations (p = 0.0078), HDL intermediate subgractions (p = 0.0451), with HDL-3 subfraction (p = 0.0229), and intermediate density lipoprotein-A (IDL-A) (p = 0.038). A significant correlation between increased diastolic blood pressure and HDL lipoprotein levels (p = 0.0454) was only observed. CONCLUSIONS: Obtained results indicating correlation between total HDL levels and HDL-3 subfraction concentration (for systolic BP) and the tendency to develop hypertension. Termedia Publishing House 2019-06-27 /pmc/articles/PMC8826797/ /pubmed/35154522 http://dx.doi.org/10.5114/aoms.2019.86197 Text en Copyright: © 2019 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Chruściel, Piotr
Stemplewska, Paulina
Stemplewski, Adam
Wattad, Mohamad
Bielecka-Dąbrowa, Agata
Maciejewski, Marek
Penson, Peter
Bartlomiejczyk, Marcin A.
Banach, Maciej
Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title_full Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title_fullStr Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title_full_unstemmed Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title_short Associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
title_sort associations between the lipid profile and the development of hypertension in young individuals – the preliminary study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826797/
https://www.ncbi.nlm.nih.gov/pubmed/35154522
http://dx.doi.org/10.5114/aoms.2019.86197
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