Molecular characterization of methicillin-resistant Staphylococcus aureus genotype ST764-SCCmec type II in Thailand

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant causative agent of hospital-acquired infections. We characterized MRSA isolated from August 2012 to July 2015 from Thammasat University Hospital. Genotypic characterization of MRSA SCCmec type II and III isolates were scrutinized by...

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Detalles Bibliográficos
Autores principales: Kondo, Sumalee, Phokhaphan, Pimonwan, Tongsima, Sissades, Ngamphiw, Chumpol, Phornsiricharoenphant, Worawich, Ruangchai, Wuthiwat, Disratthakit, Areeya, Tingpej, Pholawat, Mahasirimongkol, Surakameth, Lulitanond, Aroonlug, Apisarnthanarak, Anucha, Palittapongarnpim, Prasit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826912/
https://www.ncbi.nlm.nih.gov/pubmed/35136112
http://dx.doi.org/10.1038/s41598-022-05898-1
Descripción
Sumario:Methicillin-resistant Staphylococcus aureus (MRSA) is a significant causative agent of hospital-acquired infections. We characterized MRSA isolated from August 2012 to July 2015 from Thammasat University Hospital. Genotypic characterization of MRSA SCCmec type II and III isolates were scrutinized by whole genome sequencing (WGS). The WGS data revealed that the MRSA SCCmec type II isolates belonged to ST764 previously reported mainly in Japan. All of tested isolates contained ACME Type II′, SaPIn2, SaPIn3, seb, interrupted SA1320, and had a virulence gene profile similar to Japan MRSA ST764. Rigorous surveillance of MRSA strains is imperative in Thailand to arrest its potential spread.

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