Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an Ins1(cre) knock-in allele to delete Insr specifically in β-cells of both female and male mice. We compare ...

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Detalles Bibliográficos
Autores principales: Skovsø, Søs, Panzhinskiy, Evgeniy, Kolic, Jelena, Cen, Haoning Howard, Dionne, Derek A., Dai, Xiao-Qing, Sharma, Rohit B., Elghazi, Lynda, Ellis, Cara E., Faulkner, Katharine, Marcil, Stephanie A. M., Overby, Peter, Noursadeghi, Nilou, Hutchinson, Daria, Hu, Xiaoke, Li, Hong, Modi, Honey, Wildi, Jennifer S., Botezelli, J. Diego, Noh, Hye Lim, Suk, Sujin, Gablaski, Brian, Bautista, Austin, Kim, Ryekjang, Cras-Méneur, Corentin, Flibotte, Stephane, Sinha, Sunita, Luciani, Dan S., Nislow, Corey, Rideout, Elizabeth J., Cytrynbaum, Eric N., Kim, Jason K., Bernal-Mizrachi, Ernesto, Alonso, Laura C., MacDonald, Patrick E., Johnson, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826929/
https://www.ncbi.nlm.nih.gov/pubmed/35136059
http://dx.doi.org/10.1038/s41467-022-28039-8

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