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Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans
Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826934/ https://www.ncbi.nlm.nih.gov/pubmed/35136093 http://dx.doi.org/10.1038/s41540-022-00213-0 |
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author | Fujita, Suguru Karasawa, Yasuaki Fujii, Masashi Hironaka, Ken-ichi Uda, Shinsuke Kubota, Hiroyuki Inoue, Hiroshi Sumitomo, Yohei Hirayama, Akiyoshi Soga, Tomoyoshi Kuroda, Shinya |
author_facet | Fujita, Suguru Karasawa, Yasuaki Fujii, Masashi Hironaka, Ken-ichi Uda, Shinsuke Kubota, Hiroyuki Inoue, Hiroshi Sumitomo, Yohei Hirayama, Akiyoshi Soga, Tomoyoshi Kuroda, Shinya |
author_sort | Fujita, Suguru |
collection | PubMed |
description | Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of blood molecules by four features: (i) the decomposability into “amplitude” and “rate” components, (ii) the similarity of temporal patterns among individuals, (iii) the relation of molecules over time among individuals, and (iv) the similarity of temporal patterns among molecules. Glucose and glucose metabolism-related hormones indicated a rapid increase, and citrulline and lipids, which indicated a rapid decrease, returned to fasting levels faster than amino acids. Compared to glucose metabolism-related molecules and lipids, amino acids showed similar temporal patterns among individuals. The four features of temporal patterns of blood molecules by oral glucose ingestion characterize the differences among individuals and among molecules. |
format | Online Article Text |
id | pubmed-8826934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88269342022-02-17 Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans Fujita, Suguru Karasawa, Yasuaki Fujii, Masashi Hironaka, Ken-ichi Uda, Shinsuke Kubota, Hiroyuki Inoue, Hiroshi Sumitomo, Yohei Hirayama, Akiyoshi Soga, Tomoyoshi Kuroda, Shinya NPJ Syst Biol Appl Article Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacterized. We measured 83 metabolites and 7 hormones in 20 healthy human subjects in response to glucose ingestion. We characterized temporal patterns of blood molecules by four features: (i) the decomposability into “amplitude” and “rate” components, (ii) the similarity of temporal patterns among individuals, (iii) the relation of molecules over time among individuals, and (iv) the similarity of temporal patterns among molecules. Glucose and glucose metabolism-related hormones indicated a rapid increase, and citrulline and lipids, which indicated a rapid decrease, returned to fasting levels faster than amino acids. Compared to glucose metabolism-related molecules and lipids, amino acids showed similar temporal patterns among individuals. The four features of temporal patterns of blood molecules by oral glucose ingestion characterize the differences among individuals and among molecules. Nature Publishing Group UK 2022-02-08 /pmc/articles/PMC8826934/ /pubmed/35136093 http://dx.doi.org/10.1038/s41540-022-00213-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Fujita, Suguru Karasawa, Yasuaki Fujii, Masashi Hironaka, Ken-ichi Uda, Shinsuke Kubota, Hiroyuki Inoue, Hiroshi Sumitomo, Yohei Hirayama, Akiyoshi Soga, Tomoyoshi Kuroda, Shinya Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title | Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title_full | Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title_fullStr | Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title_full_unstemmed | Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title_short | Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
title_sort | four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826934/ https://www.ncbi.nlm.nih.gov/pubmed/35136093 http://dx.doi.org/10.1038/s41540-022-00213-0 |
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