Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 binding is observed only when Env trimers are not con...

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Detalles Bibliográficos
Autores principales: Yang, Zhi, Dam, Kim-Marie A., Bridges, Michael D., Hoffmann, Magnus A. G., DeLaitsch, Andrew T., Gristick, Harry B., Escolano, Amelia, Gautam, Rajeev, Martin, Malcolm A., Nussenzweig, Michel C., Hubbell, Wayne L., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826976/
https://www.ncbi.nlm.nih.gov/pubmed/35136084
http://dx.doi.org/10.1038/s41467-022-28424-3

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