Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters

Waning vaccine-induced immunity coupled with the emergence of SARS-CoV-2 variants has led to increases in breakthrough infections, prompting consideration for vaccine booster doses. Boosters have been reported to be safe and increase SARS-CoV-2-specific neutralizing antibody levels, but how these do...

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Detalles Bibliográficos
Autores principales: Burckhardt, Rachel M., Dennehy, John J., Poon, Leo L. M., Saif, Linda J., Enquist, Lynn W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827020/
https://www.ncbi.nlm.nih.gov/pubmed/34817198
http://dx.doi.org/10.1128/jvi.01973-21
Descripción
Sumario:Waning vaccine-induced immunity coupled with the emergence of SARS-CoV-2 variants has led to increases in breakthrough infections, prompting consideration for vaccine booster doses. Boosters have been reported to be safe and increase SARS-CoV-2-specific neutralizing antibody levels, but how these doses impact the trajectory of the global pandemic and herd immunity is unknown. Information on immunology, epidemiology, and equitable vaccine distribution should be considered when deciding the timing and eligibility for COVID-19 vaccine boosters.

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