Cargando…
Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics
Amyloid beta (Aβ) aggregation species-associated cellular stress instigates cytotoxicity and adverse cellular stiffness in neuronal cells. The study and modulation of these adverse effects demand immediate attention to tackle Alzheimer's disease (AD). We present a de novo design, synthesis and...
Autores principales: | Konar, Mouli, Ghosh, Debasis, Samanta, Sourav, Govindaraju, Thimmaiah |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827053/ https://www.ncbi.nlm.nih.gov/pubmed/35360886 http://dx.doi.org/10.1039/d1cb00235j |
Ejemplares similares
-
Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis
por: Ghosh, Debasis, et al.
Publicado: (2022) -
Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity
por: Rajasekhar, Kolla, et al.
Publicado: (2020) -
Amyloid-β-Derived Peptidomimetics Inhibits Tau
Aggregation
por: Gorantla, Nalini V., et al.
Publicado: (2021) -
Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease
por: Rajasekhar, K., et al.
Publicado: (2015) -
A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
por: Baruah, Prayasee, et al.
Publicado: (2023)