Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to the onset of the human DNA repair condition Fanconi Anaemia. Mutations in the genes coding for FA detoxifying enzymes under...

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Detalles Bibliográficos
Autores principales: Umansky, Carla, Morellato, Agustín E., Rieckher, Matthias, Scheidegger, Marco A., Martinefski, Manuela R., Fernández, Gabriela A., Pak, Oleg, Kolesnikova, Ksenia, Reingruber, Hernán, Bollini, Mariela, Crossan, Gerry P., Sommer, Natascha, Monge, María Eugenia, Schumacher, Björn, Pontel, Lucas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827065/
https://www.ncbi.nlm.nih.gov/pubmed/35136057
http://dx.doi.org/10.1038/s41467-022-28242-7

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