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Topological and enzymatic analysis of human Alg2 mannosyltransferase reveals its role in lipid-linked oligosaccharide biosynthetic pathway

N-glycosylation starts with the biosynthesis of lipid-linked oligosaccharide (LLO) on the endoplasmic reticulum (ER). Alg2 mannosyltransferase adds both the α1,3- and α1,6-mannose (Man) onto ManGlcNAc(2)-pyrophosphate-dolichol (M(1)Gn(2)-PDol) in either order to generate the branched M(3)Gn(2)-PDol...

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Detalles Bibliográficos
Autores principales:	Xiang, Meng-Hai, Xu, Xin-Xin, Wang, Chun-Di, Chen, Shuai, Xu, Si, Xu, Xiang-Yang, Dean, Neta, Wang, Ning, Gao, Xiao-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827073/ https://www.ncbi.nlm.nih.gov/pubmed/35136180 http://dx.doi.org/10.1038/s42003-022-03066-9

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