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Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study

BACKGROUND: Endogenously formed advanced glycation end products (AGEs) may be important drivers of microvascular dysfunction and the microvascular complications of diabetes. AGEs are also formed in food products, especially during preparation methods involving dry heat. OBJECTIVES: We aimed to asses...

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Autores principales: Linkens, Armand M A, Houben, Alfons J H M, Kroon, Abraham A, Schram, Miranda T, Berendschot, Tos T J M, Webers, Carroll A B, van Greevenbroek, Marleen, Henry, Ronald M A, de Galan, Bastiaan, Stehouwer, Coen D A, Eussen, Simone J M P, Schalkwijk, Casper G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827096/
https://www.ncbi.nlm.nih.gov/pubmed/34581759
http://dx.doi.org/10.1093/ajcn/nqab302
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author Linkens, Armand M A
Houben, Alfons J H M
Kroon, Abraham A
Schram, Miranda T
Berendschot, Tos T J M
Webers, Carroll A B
van Greevenbroek, Marleen
Henry, Ronald M A
de Galan, Bastiaan
Stehouwer, Coen D A
Eussen, Simone J M P
Schalkwijk, Casper G
author_facet Linkens, Armand M A
Houben, Alfons J H M
Kroon, Abraham A
Schram, Miranda T
Berendschot, Tos T J M
Webers, Carroll A B
van Greevenbroek, Marleen
Henry, Ronald M A
de Galan, Bastiaan
Stehouwer, Coen D A
Eussen, Simone J M P
Schalkwijk, Casper G
author_sort Linkens, Armand M A
collection PubMed
description BACKGROUND: Endogenously formed advanced glycation end products (AGEs) may be important drivers of microvascular dysfunction and the microvascular complications of diabetes. AGEs are also formed in food products, especially during preparation methods involving dry heat. OBJECTIVES: We aimed to assess cross-sectional associations between dietary AGE intake and generalized microvascular function in a population-based cohort. METHODS: In 3144 participants of the Maastricht Study (mean ± SD age: 60 ± 8 y, 51% men) the dietary AGEs N(ε)-(carboxymethyl)lysine (CML), N(ε)-(1-carboxyethyl)lysine (CEL), and N(δ)-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated using the combination of our ultra-performance LC–tandem MS dietary AGE database and an FFQ. Microvascular function was determined in the retina as flicker light–induced arteriolar and venular dilation and as central retinal arteriolar and venular equivalents, in plasma as a z score of endothelial dysfunction biomarkers (soluble vascular adhesion molecule 1 and soluble intracellular adhesion molecule 1, soluble E-selectin, and von Willebrand factor), in skin as the heat-induced skin hyperemic response, and in urine as 24-h albuminuria. Associations were evaluated using multiple linear regression adjusting for demographic, cardiovascular, lifestyle, and dietary factors. RESULTS: Overall, intakes of CML, CEL, and MG-H1 were not associated with the microvascular outcomes. Although higher intake of CEL was associated with higher flicker light–induced venular dilation (β percentage change over baseline: 0.14; 95% CI: 0.02, 0.26) and lower plasma biomarker z score (β: −0.04 SD; 95% CI: −0.08, −0.00 SD), the effect sizes were small and their biological relevance can be questioned. CONCLUSIONS: We did not show any strong association between habitual intake of dietary AGEs and generalized microvascular function. The contribution of dietary AGEs to generalized microvascular function should be further assessed in randomized controlled trials using specifically designed dietary interventions.
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spelling pubmed-88270962022-02-10 Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study Linkens, Armand M A Houben, Alfons J H M Kroon, Abraham A Schram, Miranda T Berendschot, Tos T J M Webers, Carroll A B van Greevenbroek, Marleen Henry, Ronald M A de Galan, Bastiaan Stehouwer, Coen D A Eussen, Simone J M P Schalkwijk, Casper G Am J Clin Nutr Original Research Communications BACKGROUND: Endogenously formed advanced glycation end products (AGEs) may be important drivers of microvascular dysfunction and the microvascular complications of diabetes. AGEs are also formed in food products, especially during preparation methods involving dry heat. OBJECTIVES: We aimed to assess cross-sectional associations between dietary AGE intake and generalized microvascular function in a population-based cohort. METHODS: In 3144 participants of the Maastricht Study (mean ± SD age: 60 ± 8 y, 51% men) the dietary AGEs N(ε)-(carboxymethyl)lysine (CML), N(ε)-(1-carboxyethyl)lysine (CEL), and N(δ)-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated using the combination of our ultra-performance LC–tandem MS dietary AGE database and an FFQ. Microvascular function was determined in the retina as flicker light–induced arteriolar and venular dilation and as central retinal arteriolar and venular equivalents, in plasma as a z score of endothelial dysfunction biomarkers (soluble vascular adhesion molecule 1 and soluble intracellular adhesion molecule 1, soluble E-selectin, and von Willebrand factor), in skin as the heat-induced skin hyperemic response, and in urine as 24-h albuminuria. Associations were evaluated using multiple linear regression adjusting for demographic, cardiovascular, lifestyle, and dietary factors. RESULTS: Overall, intakes of CML, CEL, and MG-H1 were not associated with the microvascular outcomes. Although higher intake of CEL was associated with higher flicker light–induced venular dilation (β percentage change over baseline: 0.14; 95% CI: 0.02, 0.26) and lower plasma biomarker z score (β: −0.04 SD; 95% CI: −0.08, −0.00 SD), the effect sizes were small and their biological relevance can be questioned. CONCLUSIONS: We did not show any strong association between habitual intake of dietary AGEs and generalized microvascular function. The contribution of dietary AGEs to generalized microvascular function should be further assessed in randomized controlled trials using specifically designed dietary interventions. Oxford University Press 2021-09-28 /pmc/articles/PMC8827096/ /pubmed/34581759 http://dx.doi.org/10.1093/ajcn/nqab302 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Research Communications
Linkens, Armand M A
Houben, Alfons J H M
Kroon, Abraham A
Schram, Miranda T
Berendschot, Tos T J M
Webers, Carroll A B
van Greevenbroek, Marleen
Henry, Ronald M A
de Galan, Bastiaan
Stehouwer, Coen D A
Eussen, Simone J M P
Schalkwijk, Casper G
Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title_full Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title_fullStr Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title_full_unstemmed Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title_short Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the Maastricht Study
title_sort habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function—the maastricht study
topic Original Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827096/
https://www.ncbi.nlm.nih.gov/pubmed/34581759
http://dx.doi.org/10.1093/ajcn/nqab302
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