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Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data

The risk of neurodevelopmental disorders in low birth weight (LBW) infants has gained recognition but remains debatable. We investigated the risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-aged children according to their birth weight. We conducte...

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Autores principales: Song, In Gyu, Kim, Han-Suk, Cho, Yoon-Min, Lim, You-na, Moon, Duk-Soo, Shin, Seung Han, Kim, Ee-Kyung, Park, Joonsik, Shin, Jeong Eun, Han, Jungho, Eun, Ho Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827104/
https://www.ncbi.nlm.nih.gov/pubmed/35136157
http://dx.doi.org/10.1038/s41598-022-06094-x
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author Song, In Gyu
Kim, Han-Suk
Cho, Yoon-Min
Lim, You-na
Moon, Duk-Soo
Shin, Seung Han
Kim, Ee-Kyung
Park, Joonsik
Shin, Jeong Eun
Han, Jungho
Eun, Ho Seon
author_facet Song, In Gyu
Kim, Han-Suk
Cho, Yoon-Min
Lim, You-na
Moon, Duk-Soo
Shin, Seung Han
Kim, Ee-Kyung
Park, Joonsik
Shin, Jeong Eun
Han, Jungho
Eun, Ho Seon
author_sort Song, In Gyu
collection PubMed
description The risk of neurodevelopmental disorders in low birth weight (LBW) infants has gained recognition but remains debatable. We investigated the risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-aged children according to their birth weight. We conducted a retrospective cohort study using the Korean National Health Insurance claims data of 2,143,652 children who were born between 2008 and 2012. Gestational age of infants was not available; thus, outcomes were not adjusted with it. Not only infants with birth weights of < 1.5 kg, but also 2.0–2.4 kg and 1.5–1.9 kg were associated with having ADHD; odds ratio (OR), 1.41 (95% confidence interval [CI] 1.33–1.50), and 1.49 (95% CI 1.33–1.66), respectively. The OR in infants with birth weights of 2.0–2.4 kg and 1.5–1.9 kg was 1.91 (95% CI 1.79–2.05) and 3.25 (95% CI 2.95–3.59), respectively, indicating increased odds of having ASD. Subgroup analysis for children without perinatal diseases showed similar results. In this national cohort, infants with birth weights of < 2.5 kg were associated with ADHD and ASD, regardless of perinatal history. Children born with LBW need detailed clinical follow-up.
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spelling pubmed-88271042022-02-10 Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data Song, In Gyu Kim, Han-Suk Cho, Yoon-Min Lim, You-na Moon, Duk-Soo Shin, Seung Han Kim, Ee-Kyung Park, Joonsik Shin, Jeong Eun Han, Jungho Eun, Ho Seon Sci Rep Article The risk of neurodevelopmental disorders in low birth weight (LBW) infants has gained recognition but remains debatable. We investigated the risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-aged children according to their birth weight. We conducted a retrospective cohort study using the Korean National Health Insurance claims data of 2,143,652 children who were born between 2008 and 2012. Gestational age of infants was not available; thus, outcomes were not adjusted with it. Not only infants with birth weights of < 1.5 kg, but also 2.0–2.4 kg and 1.5–1.9 kg were associated with having ADHD; odds ratio (OR), 1.41 (95% confidence interval [CI] 1.33–1.50), and 1.49 (95% CI 1.33–1.66), respectively. The OR in infants with birth weights of 2.0–2.4 kg and 1.5–1.9 kg was 1.91 (95% CI 1.79–2.05) and 3.25 (95% CI 2.95–3.59), respectively, indicating increased odds of having ASD. Subgroup analysis for children without perinatal diseases showed similar results. In this national cohort, infants with birth weights of < 2.5 kg were associated with ADHD and ASD, regardless of perinatal history. Children born with LBW need detailed clinical follow-up. Nature Publishing Group UK 2022-02-08 /pmc/articles/PMC8827104/ /pubmed/35136157 http://dx.doi.org/10.1038/s41598-022-06094-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Song, In Gyu
Kim, Han-Suk
Cho, Yoon-Min
Lim, You-na
Moon, Duk-Soo
Shin, Seung Han
Kim, Ee-Kyung
Park, Joonsik
Shin, Jeong Eun
Han, Jungho
Eun, Ho Seon
Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title_full Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title_fullStr Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title_full_unstemmed Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title_short Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data
title_sort association between birth weight and neurodevelopmental disorders assessed using the korean national health insurance service claims data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827104/
https://www.ncbi.nlm.nih.gov/pubmed/35136157
http://dx.doi.org/10.1038/s41598-022-06094-x
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