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Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy?
Transient postoperative hypocalcemia is a common complication after total thyroidectomy. Evidence on contributing metabolic factors is contradictory. Our work aims to define the role of preoperative 25-hydroxyvitaminD levels in developing transient postoperative hypocalcemia. 183 consecutive patient...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827121/ https://www.ncbi.nlm.nih.gov/pubmed/34564834 http://dx.doi.org/10.1007/s13304-021-01158-5 |
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author | Saibene, Alberto Maria Rosso, Cecilia Felisati, Giovanni Pipolo, Carlotta De Leo, Simone Lozza, Paolo Cozzolino, Mario Gennaro De Pasquale, Loredana |
author_facet | Saibene, Alberto Maria Rosso, Cecilia Felisati, Giovanni Pipolo, Carlotta De Leo, Simone Lozza, Paolo Cozzolino, Mario Gennaro De Pasquale, Loredana |
author_sort | Saibene, Alberto Maria |
collection | PubMed |
description | Transient postoperative hypocalcemia is a common complication after total thyroidectomy. Evidence on contributing metabolic factors is contradictory. Our work aims to define the role of preoperative 25-hydroxyvitaminD levels in developing transient postoperative hypocalcemia. 183 consecutive patients who underwent total thyroidectomy at our institution (May 2017–December 2019) were included in the retrospective study. We reported gender, age, estimated glomerular filtration rate, creatinine, preoperative 25-hydroxyvitaminD, serum pre- and postoperative calcium, pre- and postoperative PTH levels and transient postoperative hypocalcemia occurrences. We compared variables both among patients with and without transient postoperative hypocalcemia and between patients with different 25-hydroxyvitaminD levels (< 10 ng/ml deficitary; 11–30 ng/ml insufficient; > 30 ng/ml, normal). A binomial logistic regression model evaluating the risk for transient postoperative hypocalcemia was elaborated. Patients with transient postoperative hypocalcemia had lower levels of postoperative PTH (p < 0.001) and more frequently normal or deficitary 25-hydroxyvitaminD levels (p = 0.05). When comparing patients according to their 25-hydroxyvitaminD levels, insufficiency was associated with a lower rate of transient postoperative hypocalcemia (p = 0.05); deficiency was associated with higher preoperative PTH (p = 0.021), postoperative PTH (p = 0.043) and estimated glomerular filtration rate (p = 0.031) and lower serum creatinine (p = 0.014). In the regression model higher preoperative PTH (OR = 1.011, p = 0.041) and 25-hydroxyvitaminD deficiency (OR = 0.343, p = 0.011) significantly predicted transient postoperative hypocalcemia. Data analysis revealed a correlation between transient postoperative hypocalcemia and 25-hydroxyvitaminD levels: our work points towards the possibility to stratify the risk of transient postoperative hypocalcemia according to patients’ preoperative 25-hydroxyvitaminD status. |
format | Online Article Text |
id | pubmed-8827121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88271212022-02-23 Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? Saibene, Alberto Maria Rosso, Cecilia Felisati, Giovanni Pipolo, Carlotta De Leo, Simone Lozza, Paolo Cozzolino, Mario Gennaro De Pasquale, Loredana Updates Surg Original Article Transient postoperative hypocalcemia is a common complication after total thyroidectomy. Evidence on contributing metabolic factors is contradictory. Our work aims to define the role of preoperative 25-hydroxyvitaminD levels in developing transient postoperative hypocalcemia. 183 consecutive patients who underwent total thyroidectomy at our institution (May 2017–December 2019) were included in the retrospective study. We reported gender, age, estimated glomerular filtration rate, creatinine, preoperative 25-hydroxyvitaminD, serum pre- and postoperative calcium, pre- and postoperative PTH levels and transient postoperative hypocalcemia occurrences. We compared variables both among patients with and without transient postoperative hypocalcemia and between patients with different 25-hydroxyvitaminD levels (< 10 ng/ml deficitary; 11–30 ng/ml insufficient; > 30 ng/ml, normal). A binomial logistic regression model evaluating the risk for transient postoperative hypocalcemia was elaborated. Patients with transient postoperative hypocalcemia had lower levels of postoperative PTH (p < 0.001) and more frequently normal or deficitary 25-hydroxyvitaminD levels (p = 0.05). When comparing patients according to their 25-hydroxyvitaminD levels, insufficiency was associated with a lower rate of transient postoperative hypocalcemia (p = 0.05); deficiency was associated with higher preoperative PTH (p = 0.021), postoperative PTH (p = 0.043) and estimated glomerular filtration rate (p = 0.031) and lower serum creatinine (p = 0.014). In the regression model higher preoperative PTH (OR = 1.011, p = 0.041) and 25-hydroxyvitaminD deficiency (OR = 0.343, p = 0.011) significantly predicted transient postoperative hypocalcemia. Data analysis revealed a correlation between transient postoperative hypocalcemia and 25-hydroxyvitaminD levels: our work points towards the possibility to stratify the risk of transient postoperative hypocalcemia according to patients’ preoperative 25-hydroxyvitaminD status. Springer International Publishing 2021-09-26 2022 /pmc/articles/PMC8827121/ /pubmed/34564834 http://dx.doi.org/10.1007/s13304-021-01158-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Saibene, Alberto Maria Rosso, Cecilia Felisati, Giovanni Pipolo, Carlotta De Leo, Simone Lozza, Paolo Cozzolino, Mario Gennaro De Pasquale, Loredana Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title | Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title_full | Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title_fullStr | Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title_full_unstemmed | Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title_short | Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy? |
title_sort | can preoperative 25-hydroxyvitamin d levels predict transient hypocalcemia after total thyroidectomy? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827121/ https://www.ncbi.nlm.nih.gov/pubmed/34564834 http://dx.doi.org/10.1007/s13304-021-01158-5 |
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