The Roles of Solute Carriers in Auditory Function

Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in heari...

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Detalles Bibliográficos
Autores principales: Qian, Fuping, Jiang, Xiaoge, Chai, Renjie, Liu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827148/
https://www.ncbi.nlm.nih.gov/pubmed/35154281
http://dx.doi.org/10.3389/fgene.2022.823049
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author Qian, Fuping
Jiang, Xiaoge
Chai, Renjie
Liu, Dong
author_facet Qian, Fuping
Jiang, Xiaoge
Chai, Renjie
Liu, Dong
author_sort Qian, Fuping
collection PubMed
description Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in hearing. It has been found that mutations in some SLC members are associated with hearing loss. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification.
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spelling pubmed-88271482022-02-10 The Roles of Solute Carriers in Auditory Function Qian, Fuping Jiang, Xiaoge Chai, Renjie Liu, Dong Front Genet Genetics Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in hearing. It has been found that mutations in some SLC members are associated with hearing loss. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8827148/ /pubmed/35154281 http://dx.doi.org/10.3389/fgene.2022.823049 Text en Copyright © 2022 Qian, Jiang, Chai and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Qian, Fuping
Jiang, Xiaoge
Chai, Renjie
Liu, Dong
The Roles of Solute Carriers in Auditory Function
title The Roles of Solute Carriers in Auditory Function
title_full The Roles of Solute Carriers in Auditory Function
title_fullStr The Roles of Solute Carriers in Auditory Function
title_full_unstemmed The Roles of Solute Carriers in Auditory Function
title_short The Roles of Solute Carriers in Auditory Function
title_sort roles of solute carriers in auditory function
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827148/
https://www.ncbi.nlm.nih.gov/pubmed/35154281
http://dx.doi.org/10.3389/fgene.2022.823049
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